Inhibition of Ubiquitin Specific Peptidase 47 (USP47) was identified as a novel therapeutic target for hematologic malignancies bearing mutant oncoprotein EZH2, according to scientists from the Hefei Institutes of Physical ...
Jan 27, 2022
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Biomedical engineers at Duke University have developed a method to study how key cells in the kidneys become injured and deformed. The new model has revealed a significant mechanism behind severe kidney disease and pointed ...
Jan 26, 2022
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Researchers from The Australian National University (ANU) have identified why certain cells in the body, known as Th17 cells, go rogue and promote the onset of autoimmune diseases such as multiple sclerosis (MS).
Jan 26, 2022
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Chinese scientists recently reported the key role in tumor survival played by a histone-acetylation-regulated long noncoding RNA called lysosome cell death regulator (LCDR), providing a potential diagnostic and therapeutic ...
Jan 17, 2022
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Multiple myeloma is a cancer of the bone marrow, with a life expectancy of less than 5 years post-diagnosis. Proteasome inhibitors, the therapeutic backbone of current treatments, are very effective in treating newly diagnosed ...
Jan 12, 2022
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Research led by the Centenary Institute and University of Technology Sydney (UTS) has identified a small RNA molecule called microRNA-21 as a therapeutic target and its inhibition as a potential treatment for chronic obstructive ...
Nov 24, 2021
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A new batch of prognostic cancer biomarkers have been discovered in an area where few have gone looking before. Researchers have unveiled a catalog of 166 prognostic biomarkers, generated by analyzing long non-coding RNAs ...
Nov 15, 2021
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Researchers have identified a potential new signaling pathway and enzyme that may help further the understanding of blood clot formation in chronic kidney disease patients and ultimately be targeted for therapeutic purposes.
Nov 1, 2021
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A potent and selective enhancer of zeste homolog 2 (EZH2) inhibitor IHMT-EZH2-115 was recently discovered by researchers led by Prof. Liu Qingsong from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences ...
Nov 1, 2021
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Researchers have reversed lung fibrosis in a mouse model of idiopathic pulmonary fibrosis, or IPF, as reported in a study published in the journal Cell Death and Differentiation.
Aug 23, 2021
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