An international team of researchers led by Francesca Finotello from the Digital Science Center (DiSC) and the Department of Molecular Biology has derived a molecular signature from tumor transcriptomics data that quantifies ...
Sep 10, 2024
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Researchers at the University of Michigan Health Rogel Cancer Center have uncovered a key reason that a typically normal protein goes awry and fuels cancer.
Sep 9, 2024
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One particular protein lies at the heart of brain development. A master regulator of gene expression, it's abundantly present in neurons, and its dysfunction underlies Rett syndrome, a neurological disorder that could lead ...
Aug 26, 2024
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Scientists have discovered how interactions between RNA and the TOP1 essential enzyme, which is overexpressed in many human cancers, regulate DNA during transcription and may inform the creation of new cancer therapies, according ...
Aug 22, 2024
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The immune system is tightly regulated to ensure that it only responds to actual health threats, instead of attacking our own bodies, which happens in cases of autoimmunity. Now, researchers from Japan report a new protein–protein ...
Aug 21, 2024
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A newly discovered code within DNA—coined "spatial grammar"—holds a key to understanding how gene activity is encoded in the human genome.
Aug 20, 2024
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Everyone has moments of forgetfulness from time to time, especially as we get older. But older adults don't just have difficulty remembering new information. They also have a harder time modifying those memories when new ...
Aug 9, 2024
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A new study from the University of Michigan Health Rogel Cancer Center furthers research that suggests the potential of developing new cancer treatments to target oncogenic transcription factors by indirectly affecting their ...
Jul 30, 2024
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In a healthy human body, tissue growth and development are coordinated by many different mechanisms. Within our bodies, these mechanisms regulate the healthy growth of cells, limit their size and number, and control the timing ...
Jul 29, 2024
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Breast cancer (BC) remains one of the most challenging cancers to treat, primarily due to its heterogeneity and propensity for metastasis. The Notch signaling pathway is integral to various cellular processes and has been ...
Jul 23, 2024
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