Genetics
Scientists discover new code governing gene activity
A newly discovered code within DNA—coined "spatial grammar"—holds a key to understanding how gene activity is encoded in the human genome.
Aug 20, 2024
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News tagged with transcriptional regulation
Medical research
The largest repository of transcription factor binding data in human tissues compiled to date
Transcription factors (TFs) are proteins that bind to specific DNA sequences, regulating the transcription of genetic information from DNA to messenger RNA (mRNA). These proteins play a pivotal role in the regulation of gene ...
Oncology & Cancer
The use of new technologies expands understanding of brain tumors in children
A study used new molecular analyses to unravel the biological mechanisms of pediatric brain tumors and refine their classification. The research results were published in the journal Acta Neuropathologica Communications. ...
May 29, 2024
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Genetics
Study uncovers cell type-specific genetic insights underlying schizophrenia
Schizophrenia is a complex disease with variable presentations, and the diverse nature of this mental health disorder has made understanding the mechanisms that cause the disease, and subsequently developing effective treatments, ...
May 23, 2024
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Psychology & Psychiatry
Two studies offer key insights into the origins and potential treatment of mental health disorders
Working under the umbrella of the PsychENCODE Consortium, the mental health research project established in 2015 by the National Institutes of Health, a team of Mount Sinai scientists has uncovered important new insights ...
May 23, 2024
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Genetics
Machine learning sheds light on gene transcription
A team led by researchers at UT Southwestern Medical Center has developed deep learning models to identify a simple set of rules that govern the activity of promoters—regions of DNA that initiate the process by which genes ...
May 14, 2024
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Overweight & Obesity
Obesity disrupts normal liver function in mice, study finds
Your liver plays a vital role in your metabolism, the biological process that converts food into energy. We know that being overweight can negatively affect metabolic activity, but not exactly how. To better understand this, ...
Feb 26, 2024
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Immunology
Mettl3-dependent m6A modification is essential for effector differentiation and memory formation of CD8+ T cells
This study was led by Dr. Shuyang Yu (College of Biological Sciences, China Agricultural University), Dr. Jingyu Xu (The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University) ...
Dec 29, 2023
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Oncology & Cancer
Where DNA copying into RNA starts could determine whether cancer cells are receptive to treatment
In research published in Nature Structural & Molecular Biology, researchers from the University of Birmingham have found that transcription start sites (TSS) have a significant role in determining cancer cell behavior.
Nov 24, 2023
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Genetics
Variants of MRTFB gene linked to novel neurodevelopmental disorder
Researchers at Baylor College of Medicine have linked specific variants or mutations of the gene myocardin-related transcription factor B (MRTFB) with a novel neurodevelopmental disorder.
May 9, 2023
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