Neuroscience

How ApoE4 endangers the brain

Apolipoprotein E (ApoE) is kind of like a delivery service for the human brain. It supplies neurons with important nutrients, including with polyunsaturated fatty acids—which are building blocks of the membranes surrounding ...

Medical research

Surplus antioxidants are pathogenic for hearts and skeletal muscle

Many heart diseases are linked to oxidative stress, an overabundance of reactive oxygen species. The body reacts to reduce oxidative stress—where the redox teeter-totter has gone too far up—through production of endogenous ...

Diseases, Conditions, Syndromes

Research points to treatment for COVID-19 cytokine storms

A transgenic mouse developed at Cincinnati Children's to model the deadly childhood immune disease HLH (hemophagocytic lymphohistiocytosis) may play a key role in saving lives during the COVID-19 virus pandemic.

Neuroscience

The brain clock that keeps memories ticking

Just as members of an orchestra need a conductor to stay on tempo, neurons in the brain need well-timed waves of activity to organize memories across time. In the hippocampus—the brain's memory center—temporal ordering ...

Genetics

Researchers identify new genetic disorder

Researchers from Michigan State University College of Human Medicine and physicians from Spectrum Health have identified for the first time in a human patient a genetic disorder only previously described in animal models.

Immunology

Pathway to resolve allergic asthma is discovered

A group of Brazilian researchers succeeded in preventing allergic asthma from progressing in experimental models by increasing the amount of a certain protein. This increase, in turn, blocked the CD4+ T lymphocytes responsible ...

Neuroscience

Fights are won and lost in the brain

Researchers at the RIKEN Brain Science Institute in Japan have found that a deep-brain structure called the habenula contains two neural circuits that work in a complex interplay to influence whether a fight will be a win ...

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