Medical research

Surplus antioxidants are pathogenic for hearts and skeletal muscle

Many heart diseases are linked to oxidative stress, an overabundance of reactive oxygen species. The body reacts to reduce oxidative stress—where the redox teeter-totter has gone too far up—through production of endogenous ...

Oncology & Cancer

Chimeras offer a new way to study childhood cancers in mice

In a new paper published March 5 in the journal Cell Stem Cell, researchers in Whitehead Institute Member Rudolph Jaenisch's lab introduce a new way to model human neuroblastoma tumors in mice using chimeras—in this case, ...

Oncology & Cancer

Fibroblasts involved in healing spur tumor growth in cancer

The connective tissue cells known as fibroblasts are vitally important for our recovery from injury. Sensing tissue damage, they gravitate to the site of a wound, instigating an inflammatory response that mends damaged tissue.

Neuroscience

New study sheds light into origins of neurodegenerative disease

New research has shed light on the origins of spinocerebellar ataxia type 7 (SCA7) and demonstrates effective new therapeutic pathways for SCA7 and the more than 40 other types of spinocerebellar ataxia. The study, which ...

Medical research

Here's something that will raise your blood pressure

Many questions remain about the mechanisms that control blood pressure, particularly in relation to hypertension. Among the factors involved in regulation of blood vessel behavior, the apelin receptor (APJ) has been presumed ...

Medical research

New drug target discovered for the lung disease PAH

Scientists have identified a molecular pathway that contributes to the development of pulmonary arterial hypertension (PAH), a severe, often fatal condition that has no cure.

Medical research

Gut microbes may affect the course of ALS

Researchers at the Weizmann Institute of Science have shown in mice that intestinal microbes, collectively termed the gut microbiome, may affect the course of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's ...

page 1 from 11