Cardiology

Analytic strategy can cut bias in large observational studies

(HealthDay)—In multicenter observational studies, bias from variability in treatment selection between clinical centers can be reduced by matching recalibrated propensity scores within clinical centers, according to a study ...

Psychology & Psychiatry

Why some antidepressants may initially worsen symptoms

New research helps explain a paradoxical effect of certain antidepressants—that they may actually worsen symptoms before helping patients feel better. The findings, highlighted in a paper publishing online December 17 in ...

Medications

How new ketamine drug helps with depression

On March 5, the Food and Drug Administration (FDA) approved the first truly new medication for major depression in decades. The drug is a nasal spray called esketamine, derived from ketamine—an anesthetic that has made ...

Psychology & Psychiatry

Using ketamine to find an undiscovered pathway in depression

For the 280 million people suffering from depression globally, relief cannot come fast enough. Monoaminergic antidepressants, including selective serotonin reuptake inhibitors (SSRIs) take weeks to months to take effect and ...

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