Oxford University epidemiologist Richard Peto was puzzled by a paradox: If cancer is a function of individual cells going haywire, wouldn't an organism with a lot more cells, say a whale, have a greater chance of getting ...
Aug 28, 2019
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Scientists have shown exactly how mutations in two different genes coordinate to drive the development of malignant lung tumors, according to a new report in the open-access journal eLife.
Aug 27, 2019
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A large team of researchers affiliated with several institutions in the U.S. and one in Germany has found evidence that makes a case for a dominant-negative effect with TP53 mutations. In their paper published in the journal ...
Are you enjoying the summer? Out grilling, swimming and hiking? Beware: those sunny days may come with a cost.
Jul 31, 2019
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One of the most extensively studied genes in cancer, TP53 is well known for its role as a tumor suppressor. It senses cellular stress or damage, and in response stops cell division or initiates cell death, thereby preventing ...
Jul 30, 2019
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Investigators at St. Jude Children's Research Hospital and Massachusetts General Hospital, alongside others, have revealed the cells of origin for specific subtypes of medulloblastoma, the most common malignant pediatric ...
Jul 24, 2019
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The tumor microenvironment (TME) is a mix of fluids, immune cells and blood vessels which envelops the tumors. Interactions between tumor cells and the TME determine the progression and fate of tumors. Therefore, understanding ...
Jul 8, 2019
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St. Jude Children's Research Hospital scientists have evidence that children with acute lymphoblastic leukemia mount a robust immune response to their cancer. The findings, which appear today in the journal Science Translational ...
Jun 26, 2019
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Researchers from the Hubrecht Institute and Radboud University have developed a human model in which they use organoids, or mini organs, to study the function of specific genes that are mutated in liver cancer. Using this ...
May 23, 2019
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A new Northwestern Medicine study finds that a combination of two mutations cause a form of pediatric brain tumors to become more deadly, according to findings published in Nature Communications.
May 16, 2019
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