Metastasizing cancer cells often express integrins that provide better traction. A new study in The Journal of Cell Biology reveals how a lipid-converting enzyme helps the cells mobilize these integrins.
Jan 23, 2012
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Either heart failure or diabetes alone is bad enough, but oftentimes the two conditions seem to go together. Now, researchers reporting in the January Cell Metabolism appear to have found the culprit that leads from heart ...
Jan 3, 2012
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An inflammation-promoting protein triggers deactivation of a tumor-suppressor that usually blocks cancer formation via the NOTCH signaling pathway, a team of researchers led by scientists at The University of Texas MD Anderson ...
Dec 22, 2011
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Finding ways to counteract or disrupt the invasive nature of cancer cells, called "metastasis," has been a long-term goal of cancer researchers. Now, researchers at Moffitt Cancer Center in Tampa, Fla., have identified an ...
Dec 13, 2011
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Researchers of the Swedish medical university Karolinska Institutet and the University of Cologne, Germany, have identified a new protein involved in a defense mechanism against cancer. The VCP/p97 complex is best known for ...
Nov 28, 2011
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New discoveries about follicular lymphoma, a currently intractable form of cancer, highlight the power of functional genomics in cancer gene discovery. A report in the Oct 28th issue of Cell demonstrates how genetic insights ...
Oct 27, 2011
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The list of aging-associated proteins known to be involved in cancer is growing longer, according to research by investigators at Vanderbilt-Ingram Cancer Center and the National Institutes of Health (NIH).
Oct 17, 2011
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The p53 tumor suppressor protein is encoded by TP53, the most frequently mutated gene in cancer. A review article published in Nature Reviews Clinical Oncology by Professor Klas G Wiman and colleagues at the Department of ...
Dec 19, 2023
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During carcinogenesis, malignant cells undergo uncontrolled division, causing tumor dissemination. Target therapy is an actively developing area of cancer treatment that includes blocking the action of certain proteins that ...
Aug 2, 2018
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No specific treatments are currently available for triple negative breast cancer (TNBC), a type of tumor that lacks the receptors targeted by many breast cancer therapies. Although many TNBC tumors lack two tumor suppressors, ...
Aug 29, 2016
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