One of the most extensively studied genes in cancer, TP53 is well known for its role as a tumor suppressor. It senses cellular stress or damage, and in response stops cell division or initiates cell death, thereby preventing ...
Jul 30, 2019
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The vast majority of deadly lung cancer cases (85 percent) are termed non-small-cell lung carcinomas (NSCLCs), which often contain a mutated gene called LKB1. Salk Institute researchers have now discovered precisely why inactive ...
Jul 27, 2019
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Now, a new Salk Institute study, published on July 24, 2019, in the journal Science Advances, shows that researchers could target these hard-to-treat cancers by pursuing drugs that keep a cellular "switch," called CREB, from ...
Jul 24, 2019
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In a study published online in Nature on June 26, research teams led by Dr. Yang Weiwei at the Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences (CAS) and Dr. Li Guohui from the Dalian Institute ...
Jun 26, 2019
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A study by an international research team led by Professor Markus Kleinewietfeld (VIB-UHasselt) shows that high salt intake inhibits tumor growth in mice. The effect seems to be due to a change in function of certain immune ...
Jun 05, 2019
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Your mother was right: Broccoli is good for you. Long associated with decreased risk of cancer, broccoli and other cruciferous vegetables—the family of plants that also includes cauliflower, cabbage, collard greens, Brussels ...
May 16, 2019
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Mount Sinai researchers have broken new ground in the understanding of the MDM2 gene—which is often overexpressed in cancer—finding that when it acts with a specific protein, it can lead to cancer cell death. The study ...
May 01, 2019
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A team of international researchers has identified a process that functions like a rheostat to dial up cell division by dislodging a tumor suppressor protein that serves as an off switch. The mechanism offers insight into ...
May 01, 2019
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Analyzing both the entire set of genes and all the proteins produced by colon cancer tissues from patient samples has revealed a more comprehensive view of the tumor that points at novel cancer biological mechanisms and possible ...
Apr 25, 2019
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A few months ago, Lisa Diller saw a family for a consultation in her cancer clinic. Their story is one of tragedy, and of hope.
Apr 01, 2019
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A tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to cancer. When this gene is mutated to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with other genetic changes.
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