Diseases, Conditions, Syndromes

Ethiopia must do more to stop recurring chikungunya outbreaks

Ethiopia's second largest city, Dire Dawa, is dealing with a chikungunya fever outbreak. Around 20,000 cases of the mosquito-borne viral infection have been reported since the outbreak started in March 2019. This is the second ...

Neuroscience

Economic, fast and efficient cell-type targeting

It is a remarkable proof for the concept of IOB: working closely hand in hand, our molecular and clinical researchers have developed a library of 230 adeno associated viral vectors (AAVs), each with a different synthetic ...

Medical research

Gene therapy cassettes improved for muscular dystrophy

Experimental gene therapy cassettes for Duchenne muscular dystrophy have been modified to deliver better performance. The cassettes, which carry the therapy into muscle cells, contain newer versions of a miniaturized treatment ...

Genetics

Making gene therapy delivery safer and more efficient

Viral vectors used to deliver gene therapies undergo spontaneous changes during manufacturing which affects their structure and function, found researchers from the Perelman School of Medicine at the University of Pennsylvania ...

Neuroscience

New anti-ALS drug receives Orphan Drug designation

A new gene therapy for treating an inherited form of Amyotrophic Lateral Sclerosis has been given an Orphan Drug designation by the European Medicines Agency. The therapy is already in preclinical development at EPFL.

Genetics

A hiccup in gene therapy progress?

Zebrafish, roundworms, fruit flies, mice, rats, rabbits, dogs, cats, pigs, and monkeys provide steppingstones to clinical trials to evaluate new treatments for people. The value of animal studies continues, even after a new ...

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