Medical research

Research uncovers shortcut dendritic cells take to lymph nodes

In its response to pathogens and vaccines, the immune system relies on dendritic cells, white blood cells that patrol the body's tissues, collect components of pathogens and vaccines and transport them via lymphatic vessels ...

Immunology

Gene editing expands to new types of immune cells

In the decade since the advent of CRISPR-Cas9 gene editing, researchers have used the technology to delete or change genes in a growing number of cell types. Now, researchers at Gladstone Institutes and UC San Francisco (UCSF) ...

Oncology & Cancer

New patient guidelines on anemia and neutropenia

The National Comprehensive Cancer Network (NCCN) announced today the publication of new NCCN Guidelines for Patients: Anemia and Neutropenia, Low Red and White Blood Cell Counts funded by the NCCN Foundation and endorsed ...

Diseases, Conditions, Syndromes

Why women may be better equipped to fight COVID

When it comes to COVID-19, women seem to be the stronger sex, suffering severe disease at about half the rate as men, but the reason for this has been elusive.

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White blood cell

White blood cells (WBCs), or leukocytes (also spelled "leucocytes"), are cells of the immune system defending the body against both infectious disease and foreign materials. Five different and diverse types of leukocytes exist, but they are all produced and derived from a multipotent cell in the bone marrow known as a hematopoietic stem cell. Leukocytes are found throughout the body, including the blood and lymphatic system.

The number of leukocytes in the blood is often an indicator of disease. There are normally between 4×109 and 1.1×1010 white blood cells in a litre of blood, making up approximately 1% of blood in a healthy adult. An increase in the number of leukocytes over the upper limits is called leukocytosis, and in leukopenia, this number is much lower than the lower limit. The physical properties of leukocytes, such as volume, conductivity, and granularity, may change due to activation, the presence of immature cells, or the presence of malignant leukocytes in leukemia.

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