Acute Liver Failure

Liver damage review finds common trends

A comprehensive review of hepatotoxicity – liver damage – caused by alcohol, illicit drugs and complementary and alternative medicines has given an insight into epidemiology, risk factors, clinical manifestations, pathogenesis, ...

Feb 18, 2014
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Acute liver failure is the appearance of severe complications rapidly after the first signs of liver disease (such as jaundice), and indicates that the liver has sustained severe damage (loss of function of 80-90% of liver cells). The complications are hepatic encephalopathy and impaired protein synthesis (as measured by the levels of serum albumin and the prothrombin time in the blood). The 1993 classification defines hyperacute as within 1 week, acute as 8–28 days and subacute as 4–12 weeks. It reflects the fact that the pace of disease evolution strongly influences prognosis. Underlying etiology is the other significant determinant of outcome.

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