Acute Myeloid Leukemia

Spotting DNA repair genes gone awry

Researchers led by Ludwig Cancer Research scientist Richard Kolodner have developed a new technique for sussing out the genes responsible for helping repair DNA damage that, if left unchecked, can lead to certain cancers.

Apr 13, 2016
popularity27 comments 0

Targeting cancer with engineered T cells

Dr. Philip Greenberg, head of immunology and a member of the Clinical Research Division at Seattle's Fred Hutchinson Cancer Research Center and a leader in cancer immunology, will describe how he and colleagues are genetically ...

Apr 20, 2016
popularity4 comments 0

Acute myeloid leukemia (AML), also known as acute myelogenous leukemia, is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. AML is the most common acute leukemia affecting adults, and its incidence increases with age. Although AML is a relatively rare disease, accounting for approximately 1.2% of cancer deaths in the United States, its incidence is expected to increase as the population ages.

The symptoms of AML are caused by replacement of normal bone marrow with leukemic cells, which causes a drop in red blood cells, platelets, and normal white blood cells. These symptoms include fatigue, shortness of breath, easy bruising and bleeding, and increased risk of infection. Several risk factors and chromosomal abnormalities have been identified, but the specific cause is not clear. As an acute leukemia, AML progresses rapidly and is typically fatal within weeks or months if left untreated.

AML has several subtypes; treatment and prognosis varies among subtypes. Five-year survival varies from 15–70%, and relapse rate varies from 33-78%, depending on subtype. AML is treated initially with chemotherapy aimed at inducing a remission; patients may go on to receive additional chemotherapy or a hematopoietic stem cell transplant. Recent research into the genetics of AML has resulted in the availability of tests that can predict which drug or drugs may work best for a particular patient, as well as how long that patient is likely to survive.

This text uses material from Wikipedia licensed under CC BY-SA

Latest Spotlight News

Effects of maternal smoking continue long after birth

Early exposure to nicotine can trigger widespread genetic changes that affect formation of connections between brain cells long after birth, a new Yale-led study has found. The finding helps explains why maternal smoking ...

The brain clock that keeps memories ticking

Just as members of an orchestra need a conductor to stay on tempo, neurons in the brain need well-timed waves of activity to organize memories across time. In the hippocampus—the brain's memory center—temporal ordering ...

Fish courtship pheromone uses the brain's smell pathway

Research at the RIKEN Brain Science Institute in Japan has revealed that a molecule involved in fish reproduction activates the brain via the nose. The pheromone is released by female zebrafish and sensed by smell receptors ...

Mouse study links heart regeneration to telomere length

Researchers at the Spanish National Center for Cardiovascular Research have discovered that the ends of heart muscle cell chromosomes rapidly erode after birth, limiting the cells' ability to proliferate and replace damaged ...

Development of gut microbes and gut immunity linked

Studying twins from birth through age 2, scientists at Washington University School of Medicine in St. Louis have shown that the gut's immune system develops in sync with the gut's tens of trillions of microbes. The findings ...

Cell phones and rats: Study explores radiation exposure

For some years research teams have explored and attempted to sort out any evidence concerning a cause-effect situation with mobile phones and cancer. Interest in the question does not disappear. Scientific groups prefer to ...