A gene that is associated with regeneration of injured nerve cells has been identified by scientists at Penn State University and Duke University. The team, led by Melissa Rolls, an assistant professor of ...
Genetics Nov 01, 2012 | 5 / 5 (2) | 0
Two scientists from different generations won the Nobel Prize in medicine Monday for the groundbreaking discovery that cells in the body can be reprogrammed into completely different kinds, work that reflects ...
Medical research Oct 08, 2012 | 5 / 5 (3) | 5
DNA from cystic fibrosis patients with and without chronic infections points to unsuspected mutation
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Genetics Jul 08, 2012 | not rated yet | 0 |
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Many infections, even those caused by antibiotic-sensitive bacteria, resist treatment. This paradox has vexed physicians for decades, and makes some infections impossible to cure.
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Genetics Nov 13, 2011 | not rated yet | 0 |
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Genetics Oct 31, 2011 | not rated yet | 0 |
An over-the-counter drug used to treat diarrhea combined with minocycline, an antibiotic used to treat bacterial infections, could one day change the lives of those living with cystic fibrosis.
Medical research Apr 24, 2011 | not rated yet | 0 |
Through the serendipity of science, researchers at the University of Pittsburgh have discovered a potential treatment for deadly, drug-resistant bacterial infections that uses the same approach that HIV uses to infect cells. ...
Medical research May 07, 2013 | 5 / 5 (1) | 0 |
Johns Hopkins scientists have found out how a gout-linked genetic mutation contributes to the disease: by causing a breakdown in a cellular pump that clears an acidic waste product from the bloodstream. By comparing this ...
Medical research Apr 08, 2013 | not rated yet | 0 |
Using DNA tracking of an outbreak among cystic fibrosis patients at a treatment centre in the UK, the scientists identified frequent patient-to-patient transmission despite stringent infection control measures.
Diseases, Conditions, Syndromes Mar 28, 2013 | 5 / 5 (1) | 0 |
Among patients with the lung disorder non-cystic fibrosis bronchiectasis, treatment with the antibiotic erythromycin resulted in improvement in symptoms but also increased the risk of antibiotic resistance, according to a ...
Diseases, Conditions, Syndromes Mar 26, 2013 | not rated yet | 0 |
(Medical Xpress)—A little more than a year after the FDA approved Kalydeco (Vx-770), the first drug of its kind to treat the underlying cause of cystic fibrosis, University of Missouri researchers believe ...
Medical research Mar 21, 2013 | 4.5 / 5 (2) | 0 |
New research suggests that lowering excessive levels of a protein in immune system cells could be a strategy to clear an infection that is deadly to patients with cystic fibrosis (CF).
Medical research Jan 23, 2013 | 5 / 5 (1) | 0 |
Cystic fibrosis (also known as CF or mucoviscidosis) is a recessive genetic disease affecting most critically the lungs, and also the pancreas, liver, and intestine. It is characterized by abnormal transport of chloride and sodium across epithelium, leading to thick, viscous secretions.
The name cystic fibrosis refers to the characteristic scarring (fibrosis) and cyst formation within the pancreas, first recognized in the 1930s. Difficulty breathing is the most serious symptom and results from frequent lung infections that are treated with, though not cured by, antibiotics and other medications. Other symptoms, including sinus infections, poor growth, diarrhea, and infertility affect other parts of the body.
CF is caused by a mutation in the gene for the protein cystic fibrosis transmembrane conductance regulator (CFTR). This gene is required to regulate the components of sweat, digestive juices, and mucus. Although most people without CF have two working copies of the CFTR gene, only one is needed to prevent cystic fibrosis. CF develops when neither gene works normally and therefore has autosomal recessive inheritance.
CF is most common among Caucasians; one in 25 people of European descent carries one allele for CF.
The World Health Organization states that "In the European Union 1 in 2000-3000 newborns is found to be affected by CF".
Individuals with cystic fibrosis can be diagnosed before birth by genetic testing, or by a sweat test in early childhood. Ultimately, lung transplantation is often necessary as CF worsens.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
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