Muscular Dystrophy

Britain authorises 'three-parent' babies

Britain on Tuesday became the first country in the world to allow the creation of babies with DNA from three people after MPs voted for the controversial procedure.

Feb 03, 2015
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A look at the UK's proposal to make babies from 3 people

As British lawmakers vote Tuesday on whether to legalize the creation of babies made from the DNA of three people, here are some questions and answers about the proposed techniques and the controversy surrounding them. ...

Feb 03, 2015
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Key dates in embryonic research

Britain's House of Commons votes Tuesday on allowing the use of donated DNA to create so-called "three-parent" babies to overcome mitochondrial diseases—disorders handed down along the maternal line. ...

Feb 03, 2015
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Stem cells faulty in Duchenne muscular dystrophy

Like human patients, mice with a form of Duchenne muscular dystrophy undergo progressive muscle degeneration and accumulate connective tissue as they age. Now, researchers at the Stanford University School of Medicine have ...

Dec 17, 2014
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Muscular dystrophy (MD) is a group of muscle diseases that weaken the musculoskeletal system and hamper locomotion. Muscular dystrophies are characterized by progressive skeletal muscle weakness, defects in muscle proteins, and the death of muscle cells and tissue.

In the 1860s, descriptions of boys who grew progressively weaker, lost the ability to walk, and died at an early age became more prominent in medical journals. In the following decade, French neurologist Guillaume Duchenne gave a comprehensive account of thirteen boys with the most common and severe form of the disease, which now carries his name—Duchenne muscular dystrophy.

It soon became evident that the disease had more than one form. The other major forms are Becker, limb-girdle, congenital, facioscapulohumeral, myotonic, oculopharyngeal, distal, and Emery-Dreifuss muscular dystrophy. These diseases predominately affect males, although females may be carriers of the disease gene. Most types of MD are multi-system disorders with manifestations in body systems including the heart, gastrointestinal system, nervous system, endocrine glands, eyes and brain.

Apart from the nine major types of muscular dystrophy listed above, several MD-like conditions have also been identified. Normal intellectual, behavioral, bowel and sexual function is noticed in individuals with other forms of MD and MD-like conditions. MD-affected individuals with susceptible intellectual impairment are diagnosed through molecular characteristics but not through problems associated with disability. However, a third of patients who are severely affected with DMD may have cognitive impairment, behavioral, vision and speech problems.

This text uses material from Wikipedia licensed under CC BY-SA

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