Prognostic biomarkers ID'd in pulmonary hypertension

(HealthDay)—Biomarkers have been identified for the risk of lung transplantation and death in patients with pulmonary arterial hypertension (PAH), according to a study published online Oct. 26 in the Annals of the American ...

Nov 18, 2015
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Improper diet linked to future health complications

A Telethon Kids Institute-led study has found low levels of plasma calcium, vitamin E (alpha-tocopherol) and lutein—micronutrients found in foods like spinach and eggs—to be associated with DNA damage in children.

Nov 09, 2015
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Necrosis after cortisone injections

Injections of corticoid preparations can have severe side effects. In this issue of Deutsches Ärzteblatt International, Christian Holland and coauthors contribute to physicians' awareness of problems of this type with ...

Jun 29, 2012
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Necrosis (from the Greek νεκρός, "dead", νέκρωσις, "death, the stage of dying, the act of killing") is the premature death of cells in living tissue. Necrosis is caused by factors external to the cell or tissue, such as infection, toxins, or trauma. This is in contrast to apoptosis, which is a naturally occurring cause of cellular death. While apoptosis often provides beneficial effects to the organism, necrosis is almost always detrimental and can be fatal.

Cells that die due to necrosis do not usually send the same chemical signals to the immune system that cells undergoing apoptosis do. This prevents nearby phagocytes from locating and engulfing the dead cells, leading to a build-up of dead tissue and cell debris at or near the site of the cell death. For this reason, it is often necessary to remove necrotic tissue surgically, a process known as debridement.

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