Non Small Cell Lung Cancer
Genetic vulnerability of lung cancer to lay foundation for new drug options
Physician-researchers at UT Southwestern Medical Center have identified a vulnerability of certain lung-cancer cells – a specific genetic weakness that can be exploited for new therapies.
Cancer
Apr 04, 2013 |
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Cisplatin-resistant cancer cells sensitive to experimental anticancer drugs, PARP inhibitors
Poly (ADP-ribose) polymerase inhibitors may be a novel treatment strategy for patients with cancer that has become resistant to the commonly used chemotherapy drug cisplatin, according to data from a preclinical study published ...
Cancer
Apr 03, 2013 |
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Researchers help test cancer drug in clinical trial leading to FDA approval
The FDA has approved a thyroid cancer drug successfully tested at Virginia G. Piper Cancer Center Clinical Trials, a partnership of Scottsdale Healthcare and the Translational Genomics Research Institute (TGen).
Cancer
Mar 27, 2013 |
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Ganetespib shows potency against ALK-positive lung cancer and overcomes crizotinib resistance
A drug that indirectly impairs the function of several cancer-driving proteins, including anaplastic lymphoma kinase (ALK), may be an effective new treatment for patients with ALK—positive non-small cell lung cancer.
Cancer
Mar 26, 2013 |
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Pathologists identify patterns of mutations to help inform design of future trials
Molecular driven therapeutic targets have resulted in a paradigm shift in the treatment of advanced lung adenocarcinoma. However, in early non-small cell lung cancer (NSCLC), surgical resection remains the treatment of choice ...
Cancer
Mar 22, 2013 |
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ERCC1 not effective for guiding therapeutic decisions
(HealthDay)—Currently available antibodies for the excision repair cross-complementation group 1 (ERCC1) protein are not adequate for therapeutic decision-making regarding the potential efficacy of cisplatin-containing ...
Cancer
Mar 21, 2013 |
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Greater representation of elderly patients in Phase III trials are needed
The median age of patients diagnosed with advanced non–small-cell lung cancer (NSCLC) has steadily increased over the recent years and is presently 70 years. Despite this, the elderly are significantly underrepresented ...
Cancer
Feb 22, 2013 |
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Researchers find potential new therapeutic target for treating non-small cell lung cancer
Researchers at Moffitt Cancer Center have found a potential targeted therapy for patients with tobacco-associated non-small cell lung cancer. It is based on the newly identified oncogene IKBKE, which helps regulate immune ...
Cancer
Feb 15, 2013 |
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Stage at diagnosis only partly explains wide international variation in lung cancer survival
Stage at diagnosis only partly explains the wide variation in lung cancer survival rates among different developed countries, indicates a large study of nearly 60,000 patients, published online in Thorax.
Cancer
Feb 12, 2013 |
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SUVmax provides valuable indicator of progression-free survival in stage I NSCLC patients
SUVmax (Maximum Standardized Uptake Value) may be a significant and clinically independent marker to indicate progression-free survival in stage I non-small cell lung cancer (NSCLC) patients treated with stereotactic body ...
Cancer
Feb 08, 2013 |
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Early palliative care in lung CA focuses on coping, symptoms
(HealthDay)—Early palliative care (PC) clinic visits, integrated with standard oncologic care for patients with metastatic lung cancer, emphasize symptom management, coping, and psychosocial aspects of ...
Health
Jan 30, 2013 |
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Diabetes drug could hold promise for lung cancer patients
Ever since discovering a decade ago that a gene altered in lung cancer regulated an enzyme used in therapies against diabetes, Reuben Shaw has wondered if drugs originally designed to treat metabolic diseases ...
Cancer
Jan 29, 2013 |
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Docetaxel significantly increases survival for incurable gastric cancers
Survival for advanced stomach and oesophagael cancer patients increases by 40 per cent when treated with the chemotherapy drug, Docetaxel – providing evidence to prescribe it as a second-line treatment, ...
Cancer
Jan 23, 2013 |
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Study shows drug combination extends pancreatic cancer patient survival
A multi-center Phase III clinical trial demonstrates that Abraxane (nab-paclitaxel) plus gemcitabine is the first combination of cancer drugs to extend survival of late-stage pancreatic cancer patients compared to standard ...
Cancer
Jan 22, 2013 |
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Palliative radiation use for lung cancer higher than advised
(HealthDay)—Half of patients with metastatic non-small-cell lung cancer (NSCLC) receive at least one course of palliative radiation therapy (RT), with younger patients and those who received chemotherapy ...
Cancer
Jan 18, 2013 |
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Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC). As a class, NSCLCs are relatively insensitive to chemotherapy, compared to small cell carcinoma. When possible, they are primarily treated by surgical resection with curative intent, although chemotherapy is increasingly being used both pre-operatively (neoadjuvant chemotherapy) and post-operatively (adjuvant chemotherapy).
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