Genes & Development

Genetics

Getting straight to the heart of the matter in stem cells

The process by which embryonic stem cells develop into heart cells is a complex process involving the precisely timed activation of several molecular pathways and at least 200 genes. Now, Salk Institute scientists have found ...

Genetics

CLOCK gene may hold answers to human brain evolution

Scientists have long sought to unravel the molecular mysteries that make the human brain special: What processes drove its evolution through the millennia? Which genes are critical to cognitive development?

Oncology & Cancer

New insights into protein reveal potential therapy for breast cancer

Northwestern Medicine scientists have discovered a new function for a protein called SET1B in the cytoplasm of cells, and demonstrated that targeting its role in regulating cellular metabolism may be able to treat triple-negative ...

Genetics

Discovering a protein's role in gene expression

Northwestern Medicine scientists have discovered that a protein called BRWD2/PHIP binds to histone lysine 4 (H3K4) methylation—a key molecular event that influences gene expression—and demonstrated that it does so via ...

Genetics

Scientists identify key regulator of male fertility

When it comes to male reproductive fertility, timing is everything. Now scientists are finding new details on how disruption of this timing may contribute to male infertility or congenital illness.

Genetics

Lockdown genes to reduce IVF failure rates

Embryos kickstart a vibrant genetic program to thrive, but if the wrong genes are active the cells can self-destruct. A*STAR scientists have discovered one of the genes that needs to be tightly locked down for an embryo to ...

Cardiology

Id genes play surprise role in cardiac development

Researchers from Sanford Burnham Prebys Medical Discovery Institute (SBP), the Cardiovascular Institute at Stanford University and other institutions were surprised to discover that the four genes in the Id family play a ...

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