Journal of General Physiology

Medical research

A model-free way to characterize polymodal ion channel gating

Two studies in The Journal of General Physiology (JGP) help pave the way for a "shortcut" model-free approach to studying activation of "polymodal" ion channels—channels that open in response to multiple stimuli.

Medical research

New insights into functionality of cystic fibrosis protein

CFTR is an important protein that, when mutated, causes the life-threatening genetic disease cystic fibrosis. A study in The Journal of General Physiology (JGP) details how an accidental discovery has provided new understanding ...

Medical research

Geometry plays a role in GPCR transmembrane signaling

A recent study in The Journal of General Physiology characterizes the movement of rhodopsin, a GPCR and member of a large family of transmembrane receptors responsible for many cellular responses and involved in many human ...

Medical research

Fitting Kv potassium channels in the PIP2 puzzle

A recent study in the Journal of General Physiology brings new insights to an area of ion channel regulation: whether voltage-gated potassium (Kv) channels can be regulated by physiological changes to PIP2.

Medical research

Detailed picture of how myoV 'walks' along actin tracks

A new study in the Journal of General Physiology uses state-of-the-art fluorescence microscopy to provide a striking 3-D picture of how class V myosins (myoV) "walk" along their actin track.

Medical research

Simple, model-free analysis of voltage-gated channels

A new study in the Journal of General Physiology provides fresh insight into voltage-gated channels—transmembrane ion channels that play a critical role in the function of neuronal and muscle tissue.

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