Nature Chemical Biology

Oncology & Cancer

Drug-resistant cancer cells create own Achilles heel

The cells of most patients' cancers are resistant to a class of drugs, called proteasome inhibitors, that should kill them. When studied in the lab, these drugs are highly effective, yet hundreds of clinical trials testing ...

Medications

Finding second hits to knock out leukemia

Many new anti-cancer drugs inhibit proteins that are essential for the proliferation of cancer cells. One example is ibrutinib, an innovative therapy for chronic lymphocytic leukemia first approved in 2014. Chronic lymphocytic ...

Medical research

Discovery may lead to safer drugs to save more women in childbirth

Postpartum hemorrhaging is the world's leading cause of death for women during and after childbirth, and the third-leading cause in the United States alone. Many doctors in developing countries have turned to the drug misoprostol ...

Oncology & Cancer

'Embattled' breast cancer drugs could be revived by new discovery

More than 60 percent of breast cancer cases involve defects in the same biochemical chain of events within cancer cells—known as the PI3 kinase (PI3K) pathway—but efforts to develop therapies targeting this pathway have ...

Neuroscience

Seeing the brain's electrical activity

Neurons in the brain communicate via rapid electrical impulses that allow the brain to coordinate behavior, sensation, thoughts, and emotion. Scientists who want to study this electrical activity usually measure these signals ...

Neuroscience

Taurine lends hand to repair cells damaged in multiple sclerosis

New research suggests that administering taurine, a molecule naturally produced by human cells, could boost the effectiveness of current multiple sclerosis (MS) therapies. Scientists at The Scripps Research Institute (TSRI) ...

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