New study gives first indication that smog might trigger cell death in the heart

July 21, 2010

An early study in rats provides the first direct indication that a major component of smog might trigger cell death in the heart, researchers reported at the American Heart Association's Basic Cardiovascular Sciences 2010 Scientific Sessions - Technological and Conceptual Advances in Cardiovascular Disease.

The study found that exposure to ground-level ozone over several weeks increased the activity of a substance that triggers in the heart.

Ozone (O3) is a highly reactive gas made up of three oxygen molecules. In the , it protects Earth from the sun's radiation. However, O3 becomes a major component of smog when it forms near the ground through reactions between sunlight, and hydrocarbons from and industrial processes.

"Several epidemiological studies have linked air pollution to the development of , but contains hundreds of chemicals and those studies were unable to separate out the effects of individual components," said Rajat Sethi, Ph.D., an assistant professor in the Department of Pharmaceutical Sciences at the Texas A&M Health Science Center Irma Lerma Rangel College of Pharmacy in Kingsville, Texas. "Our study looked for direct evidence of the role of ozone alone in cardiac dysfunction by creating a controlled environment."

The researchers tested four groups of 10 rats living in clear plastic-glass boxes. The first two groups were exposed for eight hours a day to 0.8 parts per million (ppm) of O3 for either 28 or 56 consecutive days. The other two groups were exposed to 28 days or 56 days of clean, filtered air for eight hours per day. After the eight hours of testing, all the rats experienced 16 hours of clean air overnight.

The study found that the hearts of the O3-exposed rats had increased levels of tumor necrosis factor-alpha (TNF α), an indication of inflammation compared to hearts of the control rats. Increased TNF α levels have been linked to a drop in levels of a heart-protective protein called Caveolin-1 (Cav1). Scientists believe Cav1 protects the heart by binding to a chemical called p38MAPK alpha (p38MAPK α), which is known to be a cell death signaling chemical, Sethi said.

The researchers found that Cav1 levels decreased in the hearts of rats exposed to O3 compared to the hearts of control rats who breathed filtered air.

"We believe the decreased levels of Cav1 make more unbound p38MAPK α available for telling the heart cells to die. That link between Cav1 and O3 has never been shown in the heart," Sethi said.

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