Medical research

Using CRISPR to find muscular dystrophy treatments

CRISPR-Cas9 gene editing technology is best known for its potential role in correcting genetic diseases. But it can also be used as a tool to find genes that act as supporting players, making the disease better or worse. ...

Diseases, Conditions, Syndromes

How tissues harm themselves during wound healing

Most tissues of the body have the extraordinary ability to heal themselves upon injury. But sometimes something goes awry during the complex process of wound healing and the tissue forms too much connective tissue, also called ...

Medical research

Inflammation triggers fatal cycle in Alzheimer's disease

An immune reaction in the brain seems to play a major role in the development of Alzheimer's disease. In a way, it "adds fuel to the fire" and apparently causes an inflammation that, in a sense, keeps kindling itself. The ...

Oncology & Cancer

Statins starve cancer cells to death

More than 35 million Americans take statin drugs daily to lower their blood cholesterol levels. Now, in experiments with human cells in the laboratory, researchers at Johns Hopkins Medicine have added to growing evidence ...

Oncology & Cancer

One-two punch for cancer

Many cancer cells evade critical DNA surveillance and maintenance by increasing the export—by the Exportin-1 (XPO1) nucleo-cytoplasmic transport protein—of nearly all major tumor suppressor proteins from the nucleus. ...

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Programmed cell death

Programmed cell-death (or PCD) is death of a cell in any form, mediated by an intracellular program. In contrast to necrosis, which is a form of cell-death that results from acute tissue injury and provokes an inflammatory response, PCD is carried out in a regulated process which generally confers advantage during an organism's life-cycle. PCD serves fundamental functions during both plant and metazoa (multicellular animals) tissue development.

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