Powerful antioxidant resveratrol prevents metabolic syndrome in lab tests: study
Researchers in the Faculty of Medicine & Dentistry at the University of Alberta have discovered that resveratrol, a powerful antioxidant found in common foods, prevents a syndrome in some offspring that could lead to later health issues such as diabetes.
Resveratrol is found in fruits, nuts and red wine, and has been shown to extend the lifespan of many species.
Human offspring that have trouble growing in the womb have an increased risk of developing metabolic problems later in life. But U of A medical researchers Jason Dyck and Sandra Davidge and their teams found that administering resveratrol to the young offspring of lab rats after weaning actually prevented the development of a metabolic syndrome, which is characterized by glucose intolerance, insulin resistance and higher deposits of abdominal fat.
Dyck and Davidge published their findings in a recent edition of the peer-reviewed journal Diabetes. Dyck is a researcher in the departments of Pediatrics and Pharmacology, while Davidge is a researcher in the departments of Obstetrics & Gynecology and Physiology. Both are also members of the Mazankowski Alberta Heart Institute, as well as the Women and Childrens Health Research Institute. Dyck and Davidge were co-senior authors of the study.
The study took advantage of the fact that "infancy is a potential window of opportunity to intervene and prevent the future development of metabolic diseases." The researchers noted this is the first potential pharmacological treatment that may help babies that developed in a growth-restricted environment in the womb.
"There is a concept that in utero, there are genetic shifts that are occurring reprogramming is occurring because of this strenuous environment babies are in, that allows them to recover very quickly after birth," says Dyck.
"When babies are growth-restricted, they usually have a catch-up period after they are born where they catch up to non-growth-restricted groups. It might be that reprogramming that creates this kind of 'thrifty' phenotype, where they want to consume and store and get caught up.
"That reprogramming appears to make them more vulnerable to developing a host of metabolic problems."
Earlier this year, Dyck and Davidge published another paper in Diabetes demonstrating that rat offspring not growing well in the womb had noticeable side effects from high-fat diets after birth the rats deposited more fat in the abdominal area, developed glucose intolerance, more dramatic cases of insulin resistance and insulin resistance at earlier stages of life.
Dyck and Davidge are continuing their research in this area, examining whether treating the mother during pregnancy can prevent metabolic problems in rat offspring affected by intrauterine growth restriction.
Davidge is an Alberta Innovates-Health Solutions (AIHS) Scientist and a Canada Research Chair in Womens Cardiovascular Health. Dyck is an AIHS Senior Scholar and the Director of the Cardiovascular Research Centre at the U of A.
Provided by University of Alberta
- Study: Fountain of youth for your heart? Nov 02, 2007 | not rated yet | 0
- Scientists Identify New Mechanism of Insulin Resistance Jan 14, 2008 | not rated yet | 0
- Pre-pregnancy diet affects the health of future offspring Jul 02, 2011 | not rated yet | 0
- Pregnant mothers' diet linked to baby's obesity Apr 04, 2008 | not rated yet | 0
- Polycystic ovarian syndrome: New light on its causes and its effect on brothers Jun 30, 2009 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
How can there be a term called "intestinal metaplasia" of stomach
7 hours ago Hello everyone, Ok Stomach's normal epithelium is simple columnar, now in intestinal type of adenocarcinoma of stomach it undergoes "intestinal...
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013 As an experiment, for the past few months I've been consuming at least one portion of Jell-O or unflavored Knox gelatin per day. I'm 64, in very...
Alcohol and acetaminophen
May 13, 2013 Edit: sorry for the typo in the title , can't edit I looked around on google quite a bit and it's very hard to find precise information on the...
- More from Physics Forums - Medical Sciences
More news stories
Widely available in pharmacies and health stores, phosphatidylserine is a natural food supplement produced from beef, oysters, and soy. Proven to improve cognition and slow memory loss, it's a popular treatment for older ...
Medical research 1 hour ago | 5 / 5 (1) | 0 |
Researchers at Emory University have identified a protein that stimulates a pair of "orphan receptors" found in the brain, solving a long-standing biological puzzle and possibly leading to future treatments for neurological ...
Medical research 2 hours ago | not rated yet | 0 |
Australian scientists have charted the path of insulin action in cells in precise detail like never before. This provides a comprehensive blueprint for understanding what goes wrong in diabetes.
Medical research 2 hours ago | 4.5 / 5 (2) | 0 |
Researchers at the University of Illinois at Chicago College of Medicine will study gender differences in how the heart uses and stores fat—its main energy source—and how changes in fat metabolism play ...
Medical research 5 hours ago | not rated yet | 0
Nearly 20 percent of kidneys that are recovered from deceased donors in the U.S. are refused for transplant due to factors ranging from scarring in small blood vessels of the kidney's filtering units to the organ going too ...
Medical research 21 hours ago | 5 / 5 (2) | 0 |
(Medical Xpress)—Despite spending billions of dollars on research and development, drug companies have been unable to come up with effective treatments for dementia and Alzheimer's Disease (AD). Now, A. ...
33 minutes ago | 4.5 / 5 (2) | 0 |
Children with autism showed significant improvement after six months of simple sensory exercises at home using everyday items such as scents, spoons and sponges, according to UC Irvine neurobiologists.
19 minutes ago | not rated yet | 0 |
An attack on glioblastoma brain tumor cells that uses a modified poliovirus is showing encouraging results in an early study to establish the proper dose level, researchers at Duke Cancer Institute report.
24 minutes ago | not rated yet | 0
Overweight and obese patients are significantly more likely than their normal-weight counterparts to repeatedly switch primary care doctors, a practice that disrupts continuity of care and leads to more emergency room visits, ...
19 minutes ago | not rated yet | 0
Children who are exposed to secondhand smoke in early childhood are more likely to grow up to physically aggressive and antisocial, regardless of whether they were exposed during pregnancy or their parents have a history ...
56 minutes ago | 1 / 5 (1) | 0
(Medical Xpress)—Native peoples in regions where cameras are uncommon sometimes react with caution when their picture is taken. The fear that something must have been stolen from them to create the photo ...
2 hours ago | 3.5 / 5 (2) | 0 |