IADR/AADR publish study on obesity link to periodontitis

In a study titled "MicroRNA Modulation in Obesity and Periodontitis," lead author Romina Perri, University of North Carolina School of Dentistry, Oral Health Institute, conducted a pilot investigation to determine whether obesity or periodontal disease modified microRNA expression and whether there was any potential interaction between obesity and periodontitis that could involve microRNA modulation. This study is published in the Journal of Dental Research, the official publication of the International and American Associations for Dental Research (IADR/AADR).

In this investigation, total RNA was extracted from gingival biopsy samples collected from 20 patients in 4 groups (5 non-obese [BMI < 30kg/m2] participants with a healthy periodontium, 5 non-obese participants with periodontitis, 5 obese [BMI > 30kg/m2] participants with a healthy periodontium and 5 obese participants with periodontitis).

Two microRNA species (miR-18a,miR-30e) were up-regulated among with a healthy periodontium. Two microRNA species (miR-30e,miR-106b) were up-regulated in non-obese subjects with periodontal disease and in the presence of and obesity, nine microRNAs were significantly up-regulated (miR-15a,miR-18a,miR-22,miR-30d,miR-30e,miR-103,miR-106b, miR-130a,miR-142-3p,miR-185 and miR-210). The authors conclude that the data are consistent with the concept that miRNA that are induced by chronic nutritional stress leading to obesity may also non-parsimoniously modulate inflammatory pathways within periodontal tissues and affect disease expression.

"The expression of specific microRNA species in obesity provides new insight into possible mechanisms of how risk factors might modify periodontal inflammation and may represent novel therapeutic targets," said JDR Editor-in-Chief William Giannobile.

A perspective article titled "Obesity, Inflammation and : are microRNAs the Missing Link?" was co-authored by Francesco D'Aiuto and Jean Suvan, University College London Eastman Dental Institute. In it, the authors suggest that these data could represent a mechanistic breakthrough in our understanding of the modulatory effects of obesity on periodontal tissue destruction, but caution reproducibility of these findings is needed in larger and well-characterized cohorts.

More information: jdr.sagepub.com/content/early/recent

Related Stories

New cause of osteoporosis: Mutation in a miroRNA

date Nov 16, 2009

Many biological processes are controlled by small molecules known as microRNAs, which work by suppressing the expression of specific sets of genes. Xiang-Hang Luo and colleagues, at Second Xiangya Hospital of Central South ...

Useful biomarkers for esophageal squamous cell carcinoma

date Jan 25, 2011

A research team from China investigated the expression profile of miRNA in esophageal squamous cell carcinoma (ESCC). They found that miRNAs were deregulated and miR-143 and miR-145 were downregulated in ESCC.

MicroRNA controls expression of oncogenes

date Jun 09, 2008

A new study demonstrates that microRNAs can modulate the expression of well known tumor-specific oncogenic translocation proteins and may play a significant role in some human cancers. The research, published by Cell Press ...

Recommended for you

Noise from fireworks threatens young ears

date 1 hour ago

(HealthDay)—The Fourth of July weekend is a time for celebrations and beautiful fireworks displays. But, parents do need to take steps to protect their children's ears from loud fireworks, a hearing expert ...

Many new teen drivers 'crash' in simulated driving task

date 1 hour ago

(HealthDay)—Around four in 10 newly licensed teen drivers "crashed" in a simulated driving test, suggesting that many adolescents lack the skills they need to stay safe on the road, according to a new study.

Insurer Aetna to buy Humana in $35B deal

date 2 hours ago

Aetna will spend about $35 billion to buy rival Humana and become the latest health insurer bulking up on government business as the industry adjusts to the federal health care overhaul.

Feeling impulsive or frustrated? Take a nap

date 5 hours ago

Taking a nap may be an effective strategy to counteract impulsive behavior and to boost tolerance for frustration, according to a University of Michigan study.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.