Researchers reveal one reason why fat cells fail
Yale University researchers have found one of the mechanisms that cause fat cells to lose their ability to efficiently store and use energy -- a scientific mystery and a phenomenon that contributes to a major public health problem.
The Yale team discovered a mechanism that allows cellular fat droplets to expand when excess metabolic energy is present -- i.e., when the body has taken in more food than it can burn off -- helping them to take in fatty acids, the end products of our meals. The obese suffer a myriad of health problems when fat cells can no longer do this job. The scientists report their findings in the Oct. 5 issue of the journal Cell Metabolism.
"Dozens of things go wrong at the same time when cells are overwhelmed by excess fat storage, and the million-dollar question is: Which of these factors cause the breakdown of cellular balance?" said Tobias Walther, associate professor of cell biology and senior author of the study.
Walther's lab and collaborators at the Gladstone Institutes in San Francisco discovered that an enzyme within cells senses tension at the surface of the expanding fat droplets. This triggers the production of more surface components of fat droplets, enabling them to expand and accommodate more fatty acids without adverse consequences. This process is crucial for the fat cells' ability to remain in harmony with their environment.
"Without this mechanism, fat droplets within cells where energy is stored undergo quick expansion and form one big glump," rather than individual droplets, Walther said.
Walther said there are probably many such mechanisms that regulate intake and expenditure of energy as we take in food.
"The cells must balance fluctuations in energy availability, and we are exploring other mechanisms that help maintain this dynamic storage capacity," he said.
"By showing exactly how our cells are supposed to store individual fat molecules, our research offers clues about what happens when things go awry and fat accumulates in the body," said Dr. Robert Farese, Jr. a senior investigator at the Gladstone Institutes.
Provided by Yale University
- Gladstone scientists reveal the genetics of fat storage in cells May 21, 2008 | not rated yet | 0
- Scientists discover a new healthy role for fat Sep 19, 2006 | not rated yet | 0
- Cellular feast or famine Apr 05, 2011 | not rated yet | 0
- COPI complex is a regulator of lipid homeostasis Nov 25, 2008 | not rated yet | 0
- Scientists link hepatitis C virus infection to fat enzyme in liver cells Oct 10, 2010 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013 As an experiment, for the past few months I've been consuming at least one portion of Jell-O or unflavored Knox gelatin per day. I'm 64, in very...
Alcohol and acetaminophen
May 13, 2013 Edit: sorry for the typo in the title , can't edit I looked around on google quite a bit and it's very hard to find precise information on the...
Marie Curie's leukemia
May 13, 2013 Does anyone know what might be the cause of Marie Curie's cancer
- More from Physics Forums - Medical Sciences
More news stories
Nearly 20 percent of kidneys that are recovered from deceased donors in the U.S. are refused for transplant due to factors ranging from scarring in small blood vessels of the kidney's filtering units to the organ going too ...
Medical research 15 hours ago | 5 / 5 (2) | 0 |
Discovery of circadian clock in mice hair reveals period of time when damage from radiotherapy can be quickly repaired
Discovering that mouse hair has a circadian clock - a 24-hour cycle of growth followed by restorative repair - researchers suspect that hair loss in humans from toxic cancer radiotherapy and chemotherapy ...
Medical research 15 hours ago | 5 / 5 (2) | 1 |
Salamanders' immune systems are key to their remarkable ability to regrow limbs, and could also underpin their ability to regenerate spinal cords, brain tissue and even parts of their hearts, scientists have ...
Medical research 16 hours ago | 4.9 / 5 (7) | 2 |
New research from the University of Southampton has shown that blind and visually impaired people have the potential to use echolocation, similar to that used by bats and dolphins, to determine the location of an object.
Medical research 19 hours ago | not rated yet | 1 |
A novel vaccine study from South Dakota State University (SDSU) will headline the groundbreaking research that will be unveiled at the American Association of Pharmaceutical Scientists' (AAPS) National Biotechnology Conference ...
Medical research 19 hours ago | not rated yet | 0
(HealthDay)—Injections of a sugar solution appear to help relieve knee pain and stiffness related to osteoarthritis, a new study suggests.
23 minutes ago | not rated yet | 0 |
(Medical Xpress)—Scientists at the School of Medicine have shown that their previously identified therapeutic approach to fight cancer via immune cells called macrophages also prompts the disease-fighting killer T cells ...
31 minutes ago | not rated yet | 0 |
Over the past few decades, scientists have developed many devices that can reopen clogged arteries, including angioplasty balloons and metallic stents. While generally effective, each of these treatments ...
26 minutes ago | not rated yet | 0 |
(HealthDay)—Obese and overweight men and women who suffer from heartburn often report relief when they lose weight, a new study shows.
13 minutes ago | not rated yet | 0 |
(HealthDay)—When it comes to the care of your children's teeth, dentists aren't the only experts who can help.
33 minutes ago | not rated yet | 0
(HealthDay)—For patients with acute respiratory distress syndrome (ARDS), prolonged prone positioning during mechanical ventilation is associated with significantly reduced mortality at 28 and 90 days, ...
53 minutes ago | not rated yet | 0