Most powerful genetic study of psychosis to date
(Medical Xpress) -- Two genome wide studies involving more than 50,000 participants have identified new genetic risk factors for schizophrenia and bipolar disorder. The research was conducted by over 250 scientists from more than 20 countries one of the largest collaborative efforts in psychiatry to date.
The results of the Psychiatric Genome-Wide Association Study (GWAS) Consortium were published in two research papers in the October issue of Nature Genetics.
The schizophrenia study found a total of seven locations on the genome to be implicated in the disease, five of which had not been identified before. The bipolar GWAS study revealed four locations on the genome associated with the disorder, one of which has not been previously identified. Combining the findings from both studies revealed that three gene locations were involved in both disorders, confirming the genetic overlap between schizophrenia and bipolar disorder.
Schizophrenia and bipolar disorder are common and often devastating brain disorders. Some of the most prominent symptoms of schizophrenia are hallucinations and delusions. Bipolar disorder is characterized by severe, episodic mood swings. The conditions are known to be caused by a combination of genetic and environmental risk factors.
Professor David Collier from the Institute of Psychiatry at Kings College London, who was involved in both studies says: Although we have known that psychiatric disorders such as schizophrenia and bipolar disorder have a strong genetic basis, it has proven very difficult to identify the genetic risk factors involved. This is because the causes of these illnesses are highly complex, with many different genes and environmental factors involved. In order to try and solve this puzzle, hundreds of scientists researching schizophrenia have pooled their research results resulting in a major and unprecedented research cooperation, involving tens of thousands of volunteer patients.'
Prof Collier adds: These are the most powerful genetic studies of psychosis to date, and have enabled us to identify a host of new genetic risk factors. These include one gene, a micro RNA which may be acting as a master regulator, influencing the biological pathways in the brain, which once perturbed lead to schizophrenia.
Our findings are a significant advance in our knowledge of the underlying causes of psychosis - especially in relation to the development and function of the brain. Unravelling the biology of these disorders brings great hope for the development of new therapies we can attempt to develop therapeutic drugs which target the molecules in the brain involved in the development of psychosis.
IoP researchers at the MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre who contributed to the bipolar GWAS study included Professor Anne Farmer, Professor Peter McGuffin, Dr Gerome Breen, Amanda Elkin and Richard Williamson and Professor David Collier who also contributed to the schizophrenia GWAS study.
The research was funded by over 40 US National Institutes of Health grants and a similar number of government grants from many countries involved, along with substantial private and foundation support.
Sklar, P. at el. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4, Nature Genetics (October 2011) doi:10.1038/ng.943
Gejman, P.V. et al. Genome-wide association study identifies five new schizophrenia loci, Nature Genetics (October 2011) doi:10.1038/ng.940
Provided by King's College London
- Large study finds genetic 'overlap' between schizophrenia, bipolar disorder Sep 21, 2011 | not rated yet | 0
- Twin study reveals epigenetic alterations of psychiatric disorders Sep 21, 2011 | not rated yet | 0
- Genes linked to schizophrenia, bipolar disorder Sep 18, 2011 | not rated yet | 0
- Scientists identify susceptibility factor for bipolar disorder Mar 03, 2011 | not rated yet | 0
- Schizophrenia and bipolar disorder: Bridging the divide Oct 16, 2009 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011 I'd like to open a discussion thread for version 2 of the draft of my book ''Classical and Quantum Mechanics via Lie algebras'', available online at http://lanl.arxiv.org/abs/0810.1019 , and for the...
- More from Physics Forums - Independent Research
More news stories
University of Minnesota Medical School researchers from the Masonic Cancer Center, University of Minnesota, in partnership with the University's Brain Tumor Program, have developed a new mouse model of malignant peripheral ...
Genetics 31 minutes ago | not rated yet | 0 |
Northwestern University scientists have shown a gene involved in neurodegenerative disease also plays a critical role in the proper function of the circadian clock.
Genetics May 16, 2013 | 3 / 5 (1) | 1 |
Informed consent is the backbone of patient care. Genetic testing has long required patient consent and patients have had a "right not to know" the results. However, as 21st century medicine now begins to use the tools of ...
Genetics May 16, 2013 | 5 / 5 (1) | 3 |
Ethicists provide framework supporting new recommendations on reporting incidental findings in gene sequencing
In a paper published in Science Express, a group of experts led by bioethicists in the Center for Medical Ethics and Health Policy at Baylor College of Medicine provide a framework for the new American College of Medical Geneti ...
Genetics May 16, 2013 | not rated yet | 0
The use of genome-wide analysis (GWA), where the entirety of an individual's DNA is examined to look for the genomic mutations or variants which can cause health problems is a massively useful technology for diagnosing disease. ...
Genetics May 16, 2013 | not rated yet | 0
Turns out, that old "practice makes perfect" adage may be overblown. New research led by Michigan State University's Zach Hambrick finds that a copious amount of practice is not enough to explain why people ...
41 minutes ago | 5 / 5 (2) | 0 |
Older prostate cancer patients with other underlying health conditions should think twice before committing to surgery or radiation therapy for their cancer, according to a multicenter study led by researchers in the UCLA ...
28 minutes ago | not rated yet | 0 |
A new diagnostic test for a worm infection that can lead to severe enlargement and deformities of the legs and genitals is far more sensitive than the currently used test, according to results of a field ...
29 minutes ago | not rated yet | 0 |
Study shows that women who smoke during pregnancy increase the risk of both obesity and gestational diabetes in their da
Women who smoke during pregnancy increase the risk of both obesity and gestational diabetes, in their daughters, concludes research published in Diabetologia, the journal of the European Association for the Study of Diabet ...
13 minutes ago | not rated yet | 0
While Huntington's disease (HD) is currently incurable, the HD research community anticipates that new disease-modifying therapies in development may slow or minimize disease progression. The success of HD research depends ...
30 minutes ago | not rated yet | 0
Vermont became on Monday the third US state to legalize physician-assisted suicide.
24 minutes ago | not rated yet | 0