Researchers test a drug-exercise program designed to prevent type 2 diabetes
(Medical Xpress) -- Kinesiology researcher Barry Braun of the University of Massachusetts Amherst and colleagues recently reported unexpected results of a study suggesting that exercise and one of the most commonly prescribed drugs for diabetes, metformin, each improves insulin resistance when used alone, but when used together, metformin blunted the full effect of a 12-week exercise program in pre-diabetic men and women.
Insulin resistance is the root problem in pre-diabetes, a condition that often leads to Type 2 diabetes, the increasingly common disease in which the natural hormone, insulin, becomes less effective at lowering blood sugar, leading to a range of adverse health effects such as eye and nerve damage. An estimated 26 million Americans have diabetes and 69 million are pre-diabetic.
In studies funded by the American Diabetes Association and the National Institutes of Health, Braun expected to show that combining drug treatment and exercise would help to regulate blood sugar better than either treatment alone. However, the surprising result was that "exercise combined with metformin was not better than exercise alone and it might even be worse," says Braun. "Were now trying to understand the mechanisms to explain this." Findings appear in a recent issue of Diabetes Care.
Braun, with his former doctoral student Steven Malin, and colleagues recruited 32 men and women with pre-diabetes and assigned them to one of four groups, 8 per group, and asked them to follow a 12-week course of exercise, exercise plus the drug metformin, metformin alone, or no treatment. The researchers measured insulin sensitivity at baseline and again after the 12-week treatment period in the double-blind study. Exercise training consisted of 60- to 75-minutes of aerobic exercise and resistance training three times per week.
All treatment groups had improved insulin sensitivity but only the two metformin groups lost weight after 12 weeks of exercise training, metformin alone or the two combined. But as noted, adding metformin to exercise did not enhance the effects of exercise training. Rather, adding metformin seems to have blunted the positive effect of exercise by 25 to 30 percent. This is probably enough to have clinical relevance, the researchers point out.
Braun and colleagues speculate that differences in outcome for the exercise-only and the exercise-plus-metformin group may be related to differences in how muscles, the liver and the insulin-producing cells of the pancreas adapt to exercise training when metformin is present. They are now turning their attention to investigate an exercise/medication combination that more effectively targets the liver and the pancreas in the hope of creating a more effective exercise drug to prevent the transition from pre-diabetes to Type 2 diabetes.
Provided by University of Massachusetts Amherst
- Metformin and exercise combination less effective for glucose control Aug 19, 2011 | not rated yet | 0
- Dieting beats exercise for diabetes prevention, combination is best Aug 30, 2011 | not rated yet | 0
- Diabetes treatment may also provide protection against endometrial cancer Apr 05, 2011 | not rated yet | 0
- Insulin, metformin do not reduce inflammatory biomarkers for diabetes patients Sep 15, 2009 | not rated yet | 0
- Diabetes drug may prevent or delay development of polycystic ovary syndrome Jun 29, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011 I'd like to open a discussion thread for version 2 of the draft of my book ''Classical and Quantum Mechanics via Lie algebras'', available online at http://lanl.arxiv.org/abs/0810.1019 , and for the...
- More from Physics Forums - Independent Research
More news stories
A new study conducted by Boston researchers reports that the link between asthma and early childhood use of acetaminophen or ibuprofen may be driven by underlying respiratory infections that prompt the use of these analgesics, ...
Diseases, Conditions, Syndromes 10 minutes ago | not rated yet | 0
A small, easily implantable device called the Lung Volume Reduction Coil (LVRC) may play a key role in the treatment of two types of emphysema, according to a study conducted in Europe. Results of the study indicate the beneficial ...
Diseases, Conditions, Syndromes 10 minutes ago | not rated yet | 0
(HealthDay)—Vitamin D supplements may help those with Crohn's disease overcome the fatigue and decreased muscle strength associated with the inflammatory bowel disease, according to new research.
Diseases, Conditions, Syndromes 20 minutes ago | not rated yet | 0
It is impossible to predict the evolution of China's human H7N9 bird flu outbreak as researchers are still trying to understand the source of human transmission, the head of the World Health Organisation said Monday.
Diseases, Conditions, Syndromes 2 hours ago | not rated yet | 0
A new computer model could help scientists predict when a particular strain of avian influenza might become infectious from bird to human, according to a report to be published in the International Journal Data Mining an ...
Diseases, Conditions, Syndromes 3 hours ago | not rated yet | 0
New research suggests that for some hospitalized ICU patients on mechanical ventilators, using headphones to listen to their favorite types of music could lower anxiety and reduce their need for sedative medications.
10 minutes ago | not rated yet | 0 |
The early (within 24 hours of intensive care unit [ICU] admission) provision of intravenous nutrition among critically ill patients with contraindications (a condition that makes a particular procedure potentially inadvisable) ...
Having a nighttime critical care physician in the ICU doesn't improve patient outcomes, research finds
With little evidence to guide them, many hospital intensive care units (ICUs) have been employing critical care physicians at night with the notion it would improve patients' outcomes. However, new results from a one-year ...
(HealthDay)—The majority of physicians remain reluctant to adopt health information technology (HIT), according to a report by Deloitte Touche Tohmatsu.
30 minutes ago | not rated yet | 0
Air pollutants from traffic are associated with increased asthma severity levels in pregnant asthmatic women, according to a new study.
Both fine-particle air pollution and noise pollution may increase a person's risk of developing cardiovascular disease, according to German researchers who have conducted a large population study, in which both factors were ...