Standard treatments for head and neck cancer less effective in HIV-positive patients
Radiation therapy with or without chemotherapy is less effective for patients with HIV when compared to the recurrence and overall survival rates in patients who do not have HIV, according to a study presented at the Multidisciplinary Head and Neck Cancer Symposium.
Treating head and neck cancer in HIV-positive patients is a challenge for oncologists. Because of the advancements in treating HIV, these patients are living much longer and therefore have a much higher chance of developing an HIV-related cancer. However, despite using treatments that are successful in HIV-negative cancer patients, HIV-positive patients experience much worse outcomes.
In the largest single institution study of its kind, researchers retrospectively studied 71 HIV-positive head and neck cancer patients treated between 1997 and 2010. Patients were followed for approximately 47 months and the rates of recurrence and overall survival were very high at 69 percent and 55 percent, respectively. Ten percent of patients also developed a second primary malignancy within five years after receiving radiation therapy.
The study authors concluded that neither radiation nor radiation plus chemotherapy, both standard treatments for head and neck cancer, were as effective for HIV-positive patients when compared to HIV-negative patients and that more research was needed to develop treatments that can reduce the risk of recurrence and increase survival rates.
"Treating HIV-positive patients with head and neck cancers is extremely difficult, but becoming much more commonplace due to the advances in therapies that prolong the life of these patients," Waleed Mourad, MD, MSc, PhD, lead author of the study and a radiation oncologist at Beth Israel Medical Center in New York, said. "It is extremely important that we establish multimodality approaches and regimens that are better tailored to improve outcomes in HIV-positive head and neck cancer patients and minimize treated related co-morbidities."
More information: The abstract, "Outcome of HIV head and neck squamous cell carcinoma treated with RT and chemotherapy," will be presented as a poster viewing.
Provided by American Society for Radiation Oncology
- HIV-positive head and neck cancer patients benefit from radiation therapy Jan 19, 2011 | not rated yet | 0
- Radiation plus chemotherapy provides long-term positive results for head and neck cancer patients Jan 26, 2012 | not rated yet | 0
- Combination therapy spares some head and neck patients from surgery Jan 19, 2007 | not rated yet | 0
- Combining radiation and surgery significantly improves survival for head and neck cancer patients Jun 09, 2008 | not rated yet | 0
- Certain head and neck cancer patients benefit from second round of treatment Jun 13, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013 As an experiment, for the past few months I've been consuming at least one portion of Jell-O or unflavored Knox gelatin per day. I'm 64, in very...
Alcohol and acetaminophen
May 13, 2013 Edit: sorry for the typo in the title , can't edit I looked around on google quite a bit and it's very hard to find precise information on the...
Marie Curie's leukemia
May 13, 2013 Does anyone know what might be the cause of Marie Curie's cancer
- More from Physics Forums - Medical Sciences
More news stories
In a new study described in the journal Oncogene, researchers reveal how a key player in cell growth, immunity and the inflammatory response can be transformed into a primary contributor to tumor growth.
Cancer 2 hours ago | not rated yet | 0 |
A new study conducted using extensive medical records of over one million Israeli adolescents before military service shows clearly how exposure to the Israeli sun of young, light-skinned children increases substantially ...
Cancer 4 hours ago | not rated yet | 0
A new measure of the heterogeneity – the variety of genetic mutations – of cells within a tumor appears to predict treatment outcomes of patients with the most common type of head and neck cancer. In the May 20 issue ...
Cancer 8 hours ago | not rated yet | 0
Researchers at Mayo Clinic have developed a promising method to distinguish between pancreatic cancer and chronic pancreatitis—two disorders that are difficult to tell apart. A molecular marker obtained from pancreatic ...
Cancer 8 hours ago | not rated yet | 0
The use of a smartphone application significantly improves patients' preparation for a colonoscopy, according to new research presented today at Digestive Disease Week (DDW). The preparation process, which begins days in ...
Cancer May 19, 2013 | not rated yet | 0
A new computer model could help scientists predict when a particular strain of avian influenza might become infectious from bird to human, according to a report to be published in the International Journal Data Mining an ...
24 minutes ago | not rated yet | 0
Researchers at Lund University in Sweden have mapped the significance of heredity for common forms of atherosclerotic disease. No studies have previously examined whether different forms of the disease share heredity.
20 minutes ago | not rated yet | 0
It is impossible to predict the evolution of China's human H7N9 bird flu outbreak as researchers are still trying to understand the source of human transmission, the head of the World Health Organisation said Monday.
3 minutes ago | not rated yet | 0
Federal health regulators say an experimental insomnia drug from Merck can help patients fall asleep, but it also carries worrisome side effects, including daytime drowsiness and suicidal thinking.
17 minutes ago | not rated yet | 0
Over the past few decades, neuroscientists have made much progress in mapping the brain by deciphering the functions of individual neurons that perform very specific tasks, such as recognizing the location ...
2 hours ago | 5 / 5 (1) | 0 |
There is a link between use of anabolic-androgenic steroids and reduced mental health later in life. This is the main conclusion of a new study on elite male strength athletes that researchers from the University of Gothenburg ...
1 hour ago | not rated yet | 0