BPA exposure possibly linked to future heart disease

BPA exposure possibly linked to future heart disease

(HealthDay) -- Healthy people exposed to higher levels of the controversial chemical bisphenol A (BPA), found in plastics, may be more likely to develop heart disease, according to a study published online Feb. 21 in Circulation.

David Melzer, M.B., Ph.D., of the University of Exeter in the United Kingdom, and colleagues utilized data from the European Prospective Investigation of Cancer study. Respondents (aged 40 to 74 years) free of (CAD), stroke, or diabetes submitted baseline spot , and urinary (uBPA) concentrations were measured.

The researchers found that uBPA concentrations were low (median value, 1.3 ng/ml). Per each standard deviation increase in uBPA concentration (4.56 ng/ml), there was a significant association with incident CAD in models adjusted for age, sex, and urinary creatinine concentration (odds ratio [OR], 1.13; 95 percent confidence interval [CI], 1.02 to 1.24). After adjusting for CAD , including education, occupational social class, (BMI) category, systolic blood pressure, lipid concentrations, and exercise, the estimated risk was similar but narrowly missed two-sided significance (OR, 1.11; 95 percent CI, 1.00 to 1.23; P = 0.058). Sensitivity analyses conducted using the fully-adjusted model and excluding those with early CAD (<3-year follow-up), BMI >30 kg/m², or abnormal renal function; or making additional adjustments for vitamin C, C-reactive protein, or alcohol consumption, all resulted in similar estimates, and all showed associations (P ≤ 0.05) compared with controls.

"Associations between higher BPA exposure (reflected in higher urinary concentrations) and incident CAD over 10 years of follow-up showed similar trends to previously reported cross-sectional findings in the more highly-exposed National Health and Nutrition Survey respondents," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Gene variant raises risk for aortic tear and rupture

22 hours ago

Researchers from Yale School of Medicine and Celera Diagnostics have confirmed the significance of a genetic variant that substantially increases the risk of a frequently fatal thoracic aortic dissection or full rupture. ...

Considerable variation in CT use in ischemic stroke

22 hours ago

(HealthDay)—For patients with ischemic stroke there is considerable variation in the rates of high-intensity computed tomography (CT) use, according to a study published online April 8 in Circulation: Ca ...

Beating the clock for ischemic stroke sufferers

Apr 17, 2014

A ground-breaking computer technology raises hope for people struck by ischemic stroke, which is a very common kind of stroke accounting for over 80 per cent of overall stroke cases. Developed by research experts at The Hong ...

Risk for nonelective thoracic aortic sx up for uninsured

Apr 16, 2014

(HealthDay)—Uninsured patients have an increased risk of nonelective thoracic aortic operations, and have increased risks of major morbidity or mortality, according to a study published online April 8 in ...

User comments