BPA exposure possibly linked to future heart disease

BPA exposure possibly linked to future heart disease

(HealthDay) -- Healthy people exposed to higher levels of the controversial chemical bisphenol A (BPA), found in plastics, may be more likely to develop heart disease, according to a study published online Feb. 21 in Circulation.

David Melzer, M.B., Ph.D., of the University of Exeter in the United Kingdom, and colleagues utilized data from the European Prospective Investigation of Cancer study. Respondents (aged 40 to 74 years) free of (CAD), stroke, or diabetes submitted baseline spot , and urinary (uBPA) concentrations were measured.

The researchers found that uBPA concentrations were low (median value, 1.3 ng/ml). Per each standard deviation increase in uBPA concentration (4.56 ng/ml), there was a significant association with incident CAD in models adjusted for age, sex, and urinary creatinine concentration (odds ratio [OR], 1.13; 95 percent confidence interval [CI], 1.02 to 1.24). After adjusting for CAD , including education, occupational social class, (BMI) category, systolic blood pressure, lipid concentrations, and exercise, the estimated risk was similar but narrowly missed two-sided significance (OR, 1.11; 95 percent CI, 1.00 to 1.23; P = 0.058). Sensitivity analyses conducted using the fully-adjusted model and excluding those with early CAD (<3-year follow-up), BMI >30 kg/m², or abnormal renal function; or making additional adjustments for vitamin C, C-reactive protein, or alcohol consumption, all resulted in similar estimates, and all showed associations (P ≤ 0.05) compared with controls.

"Associations between higher BPA exposure (reflected in higher urinary concentrations) and incident CAD over 10 years of follow-up showed similar trends to previously reported cross-sectional findings in the more highly-exposed National Health and Nutrition Survey respondents," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Study: Removing clot helps limit stroke disability

27 minutes ago

For the first time in several decades, a new treatment has been shown to limit the damage from a common type of stroke. Researchers in the Netherlands found that mechanically removing a clot in addition to using a clot-busting ...

Growing shortage of stroke specialists seen

6 hours ago

Although stroke is the No. 4 cause of death and a leading cause of disability in the United States, there's an increasing shortage of neurologists who specialize in stroke care.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.