The leading cause of death for diabetics: Getting to the heart of problem

Millions of people suffer from type 2 diabetes. The leading cause of death in these patients is heart disease. Joseph Hill and colleagues, at the University of Texas Southwestern Medical Center, Dallas, have now identified, through their work in mice, a potential new therapeutic approach to reduce the prevalence of heart failure and improve the long-term survival of patients with type 2 diabetes.

Although diabetes-associated heart disease is caused by a multitude of factors, it is typified by changes in heart structure and function independent of high blood pressure and disease in the major arterial blood vessels. This condition is known as diabetic cardiomyopathy. The molecular mechanism(s) that links diabetes to cardiomyopathy are not well understood. Hill and colleagues found that FoxO proteins were persistently activated in the heart of mice with a condition that models and that FoxO activity was linked with the development of cardiomyopathy. Importantly, deletion of FoxO1 in markedly reduced the development of cardiomyopathy. These data led Hill and colleagues to conclude that activation of FoxO1 is critical for the development of diabetic cardiomyopathy and suggest that FoxO1 could be a promising for diabetic cardiomyopathy.

More information: www.jci.org/articles/view/60329?key=4d5e9386184f450fc9a2

Provided by Journal of Clinical Investigation

5 /5 (1 vote)
add to favorites email to friend print save as pdf

Related Stories

Faulty cell membrane repair causes heart disease

Jul 03, 2007

During vigorous exercise, heart muscle cells take a beating. In fact, some of those cells rupture, and if not for a repair process capable of resealing cell membranes, those cells would die and cause heart damage (cardiomyopathy).

A different path to fat-related heart disease

Jan 18, 2011

Heart disease is the leading cause of death for both men and women in the United States. But heart disease is more than just one disease; there are many different 'flavors' that can result from a heart attack, high blood ...

Recommended for you

Ebola virus in Africa outbreak is a new strain

18 hours ago

The Ebola virus that has killed scores of people in Guinea this year is a new strain—evidence that the disease did not spread there from outbreaks in some other African nations, scientists report.

User comments