Oncology & Cancer

Novel therapeutic targets in cutaneous squamous cell carcinoma

Cutaneous squamous cell carcinoma (cuSCC) is the second most common diagnosed malignancy in the United States, with approximately 700,000 new cases each year. Cumulative exposure to ultraviolet light is the primary environmental ...

Neuroscience

Therapeutic cooling effectively targets site of brain injury

When a newborn suffers lack of oxygen before or during birth, doctors have very little time to save precious brain tissue. The only proven effective way to treat babies with hypoxic brain injuries is by reducing body temperature ...

Oncology & Cancer

Designer probiotic treatment for cancer immunotherapy

Researchers at Columbia Engineering have engineered probiotics to safely deliver immunotherapies within tumors. These include nanobodies against two proven therapeutic targets—PD-L1 and CTLA-4. The drugs are continuously ...

Diseases, Conditions, Syndromes

New therapeutic target for acute kidney injury identified

Acute kidney injury (AKI) is common and it happens fast. Unlike chronic kidney disease, which often takes years to manifest, patients with AKI experience a rapid deterioration of kidney function over hours or days. Critically ...

Oncology & Cancer

Study finds novel molecular therapeutic target for colon cancer

Researchers have found a way to help make chemotherapy more effective in treating colon cancer. They identified a new pathway (RICTOR/mTORC2) as a biological target for the disease. Targeted inhibition of RICTOR or the mTORC2 ...

Oncology & Cancer

Researchers identify new therapeutic target for colorectal cancer

Researchers at the University of Toronto have identified a key protein that supports the growth of many colorectal cancers. The study, which will be published December 27 in the Journal of Cell Biology, reveals that a protein ...

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