Guideline: IVIg effective for certain nerve and muscle disorders
Intravenous immune globulin (IVIg) is an effective treatment for certain disorders of the nerve and muscles, including Guillain-Barré syndrome (GBS) and a form of neuropathy called chronic inflammatory demyelinating polyneuropathy (CIDP), according to a guideline issued by the American Academy of Neurology. The guideline is published in the March 27, 2012, print issue of Neurology, the medical journal of the American Academy of Neurology.
IVIg is a type of immunotherapy that fights the misdirected immune system. It is not well understood exactly how IVIg works, but it likely regulates an overactive immune system. Immune globulin is a protein in human blood that likely links itself with antibodies or other substances directed at the nerve.
According to the guideline, strong evidence shows that IVIg effectively treats Guillain-Barré syndrome, a rare disorder in which the body's immune system attacks the peripheral nervous system, causing tingling and weakness in the arms and legs. The evidence shows that IVIg works as well as the treatment called plasma exchange to treat GBS.
Strong evidence also shows that long-term use of IVIg can help treat CIDP, which is the chronic counterpart of GBS and can affect nerves in the arms and legs and other parts of the body.
"Serious side effects are rare with IVIg, but there is a risk of kidney failure and a condition that causes the blood to be more likely to form clots," said guideline lead author Huned S. Patwa, MD, of Yale University and the VA Connecticut Healthcare System in West Haven and a member of the American Academy of Neurology. "It is important to work with your doctor when deciding whether to use IVIg for a neuromuscular disorder."
The guideline also found that IVIg is effective in helping to treat moderate to severe forms of myasthenia gravis and a rare condition known as multifocal motor neuropathy. It may also be helpful in treating neuromuscular disorders known as nonresponsive dermatomyositis and Lambert-Eaton myasthenic syndrome.
Provided by American Academy of Neurology
- AAN guideline: Plasma exchange effective in treating severe MS relapses, neuropathies Jan 17, 2011 | not rated yet | 0
- Immunotherapy linked to lower risk of Alzheimer's disease Jul 20, 2009 | not rated yet | 0
- New study may redefine how a chronic auto-immune disease is diagnosed Jun 10, 2009 | not rated yet | 0
- Better and more affordable treatments for sufferers of autoimmune diseases Dec 13, 2011 | not rated yet | 0
- AAN issues new guideline on best treatments for diabetic nerve pain Apr 11, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
How can there be villous adenoma in colon, if there are no villi there
6 hours ago As title suggest. Thanks :smile:
How can there be a term called "intestinal metaplasia" of stomach
May 21, 2013 Hello everyone, Ok Stomach's normal epithelium is simple columnar, now in intestinal type of adenocarcinoma of stomach it undergoes "intestinal...
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013 As an experiment, for the past few months I've been consuming at least one portion of Jell-O or unflavored Knox gelatin per day. I'm 64, in very...
- More from Physics Forums - Medical Sciences
More news stories
Moving objects attract greater attention – a fact exploited by video screens in public spaces and animated advertising banners on the Internet. For most animal species, moving objects also play a major ...
Neuroscience 1 minute ago | not rated yet | 0 |
It is known that signs of neurological disorders such as Alzheimer's and Huntington's disease can appear years before the disease becomes manifest; these signs take the form of subtle changes in the brain and behavior of ...
Neuroscience 5 minutes ago | not rated yet | 0
Scientists have reversed behavioral and brain abnormalities in adult mice that resemble some features of schizophrenia by restoring normal expression to a suspect gene that is over-expressed in humans with ...
Neuroscience 1 hour ago | not rated yet | 0 |
Researchers at Johns Hopkins have unraveled the molecular foundations of cocaine's effects on the brain, and identified a compound that blocks cravings for the drug in cocaine-addicted mice. The compound, already proven safe ...
Neuroscience 1 hour ago | not rated yet | 0 |
New research shows that craving drugs such as nicotine can be visualized in specific regions of the brain that are implicated in determining the value of actions, in planning actions and in motivation. Dr. Alain Dagher, from ...
Neuroscience 3 hours ago | not rated yet | 0
Researchers from Queen Mary, University of London have led the largest sequencing study of human disease to date, investigating the genetic basis of six autoimmune diseases.
47 minutes ago | not rated yet | 0 |
Swiss scientists reveal the mechanism responsible for aging hidden deep within mitochondria—and dramatically slow it down in worms by administering antibiotics to the young.
46 minutes ago | 4 / 5 (1) | 0 |
The human gut is loaded with commensal bacteria – "good" microbes that, among other functions, help the body digest food. The gastrointestinal tract contains literally trillions of such cells, and yet the ...
43 minutes ago | not rated yet | 0 |
When turned on, the gene p53 turns off cancer. However, when existing drugs boost p53, only a few tumors die – the rest resist the challenge. A study published in the journal Cell Reports shows how: tumors that live even i ...
1 minute ago | not rated yet | 0 |
Top AIDS scientists were optimistic Wednesday of finding a cure for the disease that has claimed 30 million lives—but said it might not work for all people.
27 minutes ago | not rated yet | 0
A new study provides neurobiological evidence for dysfunction in the neural circuitry underlying emotion regulation in people with insomnia, which may have implications for the risk relationship between insomnia and depression.
4 minutes ago | not rated yet | 0