Polymorphism in opioid gene affects breast cancer survival

March 30, 2012
Polymorphism in opioid gene affects breast cancer survival
Genotype at the A118G polymorphism of the µ-opioid receptor gene is associated with breast cancer-specific mortality, according to a study published in the April issue of Anesthesiology.

(HealthDay) -- Genotype at the A118G polymorphism of the µ-opioid receptor gene is associated with breast cancer-specific mortality, according to a study published in the April issue of Anesthesiology.

Preclinical studies suggest that opioids may have a tumor-promoting effect. To investigate the association between common polymorphisms, including the A118G , in the µ-opioid receptor gene and survival, Andrey V. Bortsov, M.D., Ph.D., of the University of North Carolina at Chapel Hill, and colleagues followed 2,039 women diagnosed with breast cancer in 1993 to 2001, through 2006. The women, aged 23 to 74 years, were genotyped using the TaqMan platform.

The researchers found that patient genotype at A118G correlated with breast cancer-specific mortality at 10 years. Significantly decreased breast cancer-specific mortality was seen for women with one or more copies of the G allele. The correlation was seen only for invasive cases and the effect size seemed to increase with clinical stage. Compared with the A/A , significantly decreased mortality was seen for women with the A/G and G/G genotypes, after adjusting for age and ethnicity (hazard ratios 0.57 and 0.32, respectively).

"The results of this study provide support for the hypothesis that endogenous and/or exogenous opioids, acting via the µ-opioid receptor, may influence cancer outcomes," the authors write.

Explore further: Childbearing may increase risk of hormone receptor-negative breast cancer in African-American women

More information: Abstract
Full Text

Related Stories

Breast cancer type linked to paternal cancer

November 28, 2011

The risk of breast cancer is increased by genetic and lifestyle factors such as the inherited BRCA2 gene, age of having first child, or use of hormone replacement therapy (HRT). New research published in BioMed Central's ...

Breast cancer mortality higher in Hispanic women

December 8, 2011

Hispanic women are more likely to die from breast cancer than non-Hispanic white women, according to research presented at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium, held Dec. 6-10, 2011.

Evidence mounts for link between opioids and cancer growth

March 20, 2012

Opioid drugs used to relieve pain in postoperative and chronic cancer patients may stimulate the growth and spread of tumors, according to two studies and a commentary in the 2012 annual Journal Symposium issue of Anesthesiology, ...

Recommended for you

Researchers thwart cancer cells by triggering 'virus alert'

August 27, 2015

Working with human cancer cell lines and mice, researchers at the Johns Hopkins Kimmel Cancer Center and elsewhere have found a way to trigger a type of immune system "virus alert" that may one day boost cancer patients' ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.