Treating psoriasis to prevent heart attacks and strokes

March 16, 2012

A clinical study co-led by the Montreal Heart Institute and Innovaderm Research Inc., which was presented today at the annual meeting of the American Academy of Dermatology, shows that a new treatment for psoriasis could be associated with a significant decrease in vascular inflammation, a major risk factor of cardiovascular disease.

Psoriasis is a of the skin and joints that affects up to 3% of the population. This disease is associated with a greater risk of (infarction) and stroke. The goal of this clinical study was to show that a treatment to reduce in psoriasis patients could be associated with a decrease in vascular inflammation.

The study had positive results, as vascular inflammation decreased significantly in patients suffering from psoriasis who were treated with adalimumab, a biological anti-inflammatory compound. The study also showed a 51% decrease in C-reactive protein among patients treated with adalimumab compared to a 2% decrease among patients in the . These results are significant, as a high level of C-reactive protein is known to be associated with an increased and stroke. In relation to the treatment of psoriasis, 70% of patients who received the compound presented with a major decrease in skin lesion severity, compared to 20% of patients in the control group.

According to Dr. Robert Bissonnette, President and Founder of Innovaderm Research Inc. and co-principal author of the study, who will present the findings at the annual meeting of the American Academy of Dermatology, "This study is a great example of the high-level research being conducted in Montréal. "He added that this clinical research study suggests that it is possible to assess the impact of psoriasis treatments on the heart without having to resort to long-term studies that require thousands of patients and have higher costs.

"These findings are extremely encouraging for people suffering from psoriasis, as they face a greater risk of cardiovascular disease," explained Dr. Jean-Claude Tardif, Director of the Research Centre of the Montreal Heart Institute and co-principal author of the study. He also emphasized the importance of regular medical follow-up for people with psoriasis to prevent cardiovascular events and establish an optimum therapeutic approach.

Imaging as a vascular inflammation measurement tool

Between May 2009 and June 2011, 30 patients suffering from moderate to severe and with a history of coronary artery disease or multiple associated were followed for four months as part of a randomized clinical study. The patients were divided into two groups: the first group was treated with sub-cutaneous injections of while the second group received no treatment or a routine treatment (i.e., topical formulation, phototherapy). Each patient's level of vascular inflammation was measured at the start and end of the study with positron emission tomography (PET), a type of medical imaging, to scan the carotid arteries and the ascending aorta.

Explore further: Patients with severe psoriasis need evaluation of heart disease risk

Related Stories

Psoriasis is associated with impaired HDL function

November 16, 2011

Collaborative research from Perelman School of Medicine at the University of Pennsylvania has shown that psoriasis patients have an increased risk of heart attack, stroke and cardiovascular death, especially if the psoriasis ...

UVB preferred for treatment of moderate to severe psoriasis

February 24, 2012

(HealthDay) -- Ultraviolet B (UVB) is preferred by dermatologists for first-line treatment of moderate to severe psoriasis in both healthy male and female patients, according to a study published in the March issue of the ...

Recommended for you

Zika virus may persist in the vagina days after infection

August 25, 2016

The Zika virus reproduces in the vaginal tissue of pregnant mice several days after infection, according to a study by Yale researchers. From the genitals, the virus spreads and infects the fetal brain, impairing fetal development. ...

In sub-Saharan Africa, cancer can be an infectious disease

August 26, 2016

In 1963, Irish surgeon Denis Parson Burkitt airmailed samples of an unusual jaw tumor found in Ugandan children to his colleague, Anthony Epstein, at Middlesex Hospital in London. Epstein, an expert in chicken viruses and ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.