Vitamin D analogs modulate immunity in psoriasis

March 9, 2012 in Diseases, Conditions, Syndromes

Vitamin D analogs modulate immunity in psoriasis

Vitamin D3 analogs modulate immunity in human psoriasis, inducing thymic stromal lymphopoietin and cathelicidin, according to a study published online March 2 in the British Journal of Dermatology.

(HealthDay) -- Vitamin D3 analogs modulate immunity in human psoriasis, inducing thymic stromal lymphopoietin (TSLP) and cathelicidin, according to a study published online March 2 in the British Journal of Dermatology.

To determine whether analogs also have immune modulating effects in human psoriasis, Emi Deguchi, M.D., and colleagues from Fukuoka University in Japan, examined cytokine levels in skin biopsies from psoriatic lesions from 10 patients not treated with vitamin D3 analogs and 10 patients treated with topical vitamin D3 analogs.

The researchers found that, compared with samples from patients not treated with vitamin D3 analogs, samples from patients treated with vitamin D3 analogs had significantly higher levels of TSLP, thymus and activation-related chemokine, and C-C chemokine receptor type 4. Cathelicidin expression was also higher in these patients. Patients treated with vitamin D3 analogs had significantly lower levels of (IL)-12/IL-23 p40, IL-1α, IL-1β, and TNF-α.

"Topical vitamin D3 analogs induced TSLP and cathelicidin in psoriatic lesion, resulting in suppression of IL-12/IL-23 p40, IL-1α, IL-1β, and TNF-α, thereby ameliorating psoriatic plaque," Deguchi and colleagues conclude.

More information: Abstract
Full Text (subscription or payment may be required)

Journal reference: British Journal of Dermatology search and more info website

Copyright © 2012 HealthDay. All rights reserved.

5 /5 (2 votes)  

Filter


Move the slider to adjust rank threshold, so that you can hide some of the comments.


Display comments: newest first

cyberCMDR
Mar 09, 2012

Rank: not rated yet
Can these analogues be taken internally, for people with autoimmune diseases?
Rank 5 /5 (2 votes)
Relevant PhysicsForums posts

More news stories

Mild hypothyroidism raises mortality risk among heart failure patients

Patients with underlying heart failure are more likely to experience adverse outcomes from mild hypothyroidism, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & ...

Diseases, Conditions, Syndromes created 1 hour ago | popularity not rated yet | comments 0

Acne treatment: Natural substance-based formula is more effective than artificial compounds

University of Granada scientists have patented a new treatment for acne that is based on completely natural substances and is much more effective than artificial formulas because it does not create resistance ...

Diseases, Conditions, Syndromes created 3 hours ago | popularity not rated yet | comments 0

Study finds COPD is over-diagnosed among uninsured patients

More than 40 percent of patients being treated for COPD at a federally funded clinic did not have the disease, researchers found after evaluating the patients with spirometry, the diagnostic "gold standard" for chronic obstructive ...

Diseases, Conditions, Syndromes created 5 hours ago | popularity not rated yet | comments 0

Mysterious illness kills two in southeast Alabama

(AP)—Alabama health officials say a mysterious respiratory illness has left five people hospitalized and two dead in the southeastern part of the state.

Diseases, Conditions, Syndromes created 8 hours ago | popularity not rated yet | comments 0

Researchers find genetic risk factor for pulmonary fibrosis

A paper recently published in the New England Journal of Medicine and co-written by physicians and scientists at the University of Colorado School of Medicine finds that an important genetic risk factor for pulmonary fibros ...

Diseases, Conditions, Syndromes created 21 hours ago | popularity not rated yet | comments 0


Enzyme-activating antibodies revealed as marker for most severe form of rheumatoid arthritis

In a series of lab experiments designed to unravel the workings of a key enzyme widely considered a possible trigger of rheumatoid arthritis, researchers at Johns Hopkins have found that in the most severe ...

Researchers complete largest genetic sequencing study of human disease

Researchers from Queen Mary, University of London have led the largest sequencing study of human disease to date, investigating the genetic basis of six autoimmune diseases.

Slowing the aging process—only with antibiotics

Swiss scientists reveal the mechanism responsible for aging hidden deep within mitochondria—and dramatically slow it down in worms by administering antibiotics to the young.

Research offers promising new approach to treatment of lung cancer

Researchers have developed a new drug delivery system that allows inhalation of chemotherapeutic drugs to help treat lung cancer, and in laboratory and animal tests it appears to reduce the systemic damage ...

Overeating learned in infancy, study suggests

In the long run, encouraging a baby to finish the last ounce in their bottle might be doing more harm than good.

Researchers analyse hunting behaviour of fish larvae in virtual reality

Moving objects attract greater attention – a fact exploited by video screens in public spaces and animated advertising banners on the Internet. For most animal species, moving objects also play a major ...