Drug treatment for urinary incontinence effective, but side-effects can derail success

Women with UI suffer physical, psychological, and social consequences of not being in full control of their bladders.

Women with mild UI may occasionally leak urine when they cough or sneeze, while women with more severe UI may have extreme, sudden urges to urinate that can result in embarrassing accidents. Standard treatment for women with urgency UI includes , pelvic floor , and bladder training. In addition, several drugs have been approved for adults with with or without urgency UI.

Researchers systematically reviewed 94 published randomized controlled trials to determine the safety and efficacy of drugs available in the U.S. for urinary incontinence. The researches focused on continence and quality of life as primary outcomes. Fifty percent or more reduction in daily UI episodes was defined as a clear, clinically important response to treatment.

Adverse effects and treatment discontinuation due to side-effects also were examined. The researchers found that drugs were more effective than placebo in achieving continence and improving UI, but the improvements were small and treatment discontinuation due to bothersome adverse effect was frequent.

Few studies were available to compare one drug to another. Among individual drug comparisons, festerodine was more effective than tolterodine in achieving continence and improving UI. Discontinuation due to adverse effects occurred more often with fesoterodine or oxybutynin than with tolterodine. The lowest rates of treatment discontinuation with 5 mg of solifenacin.

The researchers conclude that should be based on side-effects profile and patient preferences.

Provided by American College of Physicians

2.5 /5 (2 votes)
add to favorites email to friend print save as pdf

Related Stories

Recommended for you

WHO: Ebola vaccine trials in W. Africa in January

9 hours ago

Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe, a top World Health Organization official ...

Ebola cases rise sharply in western Sierra Leone

9 hours ago

After emerging months ago in eastern Sierra Leone, Ebola is now hitting the western edges of the country where the capital is located with dozens of people falling sick each day, the government said Tuesday. So many people ...

User comments