Oxiplex improves outcomes after lumbar discectomy

April 24, 2012
Oxiplex improves outcomes after lumbar discectomy

(HealthDay) -- The use of Oxiplex gel (containing carboxymethylcellulose, polyethylene oxide, and calcium) to coat the surgical site during discectomy procedures for the treatment of lumbar disc herniation is associated with improved clinical outcomes, according to a study published in the April 15 issue of Spine.

Alfred L. Rhyne, M.D., of the OrthoCarolina Spine Center in Charlotte, N.C., and colleagues conducted a prospective, randomized, blinded clinical trial involving 177 patients who received Oxiplex gel following lumbar discectomy and 175 surgery-only control patients. Patients completed the Lumbar Spine Outcomes Questionnaire to assess quality of life, and underwent clinical evaluations at six months post-surgery.

The researchers found that, compared with control patients, more gel-treated patients were satisfied with the outcome of their surgery. Greater reductions in pain and symptoms were seen for gel-treated versus control patients. In a subgroup of patients with substantial back pain at baseline, gel-treatment was associated with a significant and consistent reduction in leg and back pain at six months. Compared with controls, fewer gel-treated patients had abnormal musculoskeletal physical examinations at six months. Fewer gel-treated patients reported hypoesthesia, paraesthesia, , or reoperations during the six-month follow-up period.

"These data demonstrate multiple improvements in clinical outcome compared with that achieved by surgery alone due to the addition of Oxiplex gel to discectomy for treatment of lumbar herniation," the authors write.

The study was supported by corporate/industry funds; several authors disclosed potential financial , including to FzioMed, the manufacturer of Oxiplex gel.

Explore further: Surgical treatment within six months of lumbar disc herniation

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Pattern of disc degeneration impacts low back pain

April 12, 2012

(HealthDay) -- Contiguous, multilevel disc degeneration (CMDD) is associated with increased likelihood of low back pain (LBP) and pain severity compared with skipped level disc degeneration (SLDD), according to a study published ...

FDA: clinicians urged to stop using certain ultrasound gel

April 19, 2012

(HealthDay) -- Hospitals, clinics, and health care professionals should immediately discontinue using Other-Sonic Generic Ultrasound Transmission Gel due to risk of bacterial contamination in certain batches, according to ...

Recommended for you

The 'love hormone' may quiet tinnitus

September 23, 2016

(HealthDay)—People suffering from chronic ringing in the ears—called tinnitus—may find some relief by spraying the hormone oxytocin in their nose, a small initial study by Brazilian researchers suggests.

Bile acid uptake inhibitor prevents NASH / fatty liver in mice

September 21, 2016

Drugs that interfere with bile acid recycling can prevent several aspects of NASH (nonalcoholic steatohepatitis) in mice fed a high-fat diet, scientists from Emory University School of Medicine and Children's Healthcare of ...

New therapeutic target for Crohn's disease

September 20, 2016

Research from the Sanford Burnham Prebys Medical Discovery Institute (SBP) identifies a promising new target for future drugs to treat inflammatory bowel disease (IBD). The study, published today in Cell Reports, also indicates ...

Mosquitoes, Zika and biotech regulation

September 19, 2016

In a new Policy Forum article in Science, NC State professor Jennifer Kuzma argues that federal authorities are missing an opportunity to revise outdated regulatory processes not fit for modern innovations in biotechnology, ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.