Oxiplex improves outcomes after lumbar discectomy

Oxiplex improves outcomes after lumbar discectomy

(HealthDay) -- The use of Oxiplex gel (containing carboxymethylcellulose, polyethylene oxide, and calcium) to coat the surgical site during discectomy procedures for the treatment of lumbar disc herniation is associated with improved clinical outcomes, according to a study published in the April 15 issue of Spine.

Alfred L. Rhyne, M.D., of the OrthoCarolina Spine Center in Charlotte, N.C., and colleagues conducted a prospective, randomized, blinded clinical trial involving 177 patients who received Oxiplex gel following lumbar discectomy and 175 surgery-only control patients. Patients completed the Lumbar Spine Outcomes Questionnaire to assess quality of life, and underwent clinical evaluations at six months post-surgery.

The researchers found that, compared with control patients, more gel-treated patients were satisfied with the outcome of their surgery. Greater reductions in pain and symptoms were seen for gel-treated versus control patients. In a subgroup of patients with substantial back pain at baseline, gel-treatment was associated with a significant and consistent reduction in leg and back pain at six months. Compared with controls, fewer gel-treated patients had abnormal musculoskeletal physical examinations at six months. Fewer gel-treated patients reported hypoesthesia, paraesthesia, , or reoperations during the six-month follow-up period.

"These data demonstrate multiple improvements in clinical outcome compared with that achieved by surgery alone due to the addition of Oxiplex gel to discectomy for treatment of lumbar herniation," the authors write.

The study was supported by corporate/industry funds; several authors disclosed potential financial , including to FzioMed, the manufacturer of Oxiplex gel.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Surgical treatment within six months of lumbar disc herniation

Oct 25, 2011

A new study in the Journal of Bone and Joint Surgery (JBJS) found that patients with herniated lumbar disc symptoms were significantly worse if the patients had symptoms for more than six months prior to treatment, compared to t ...

Pattern of disc degeneration impacts low back pain

Apr 12, 2012

(HealthDay) -- Contiguous, multilevel disc degeneration (CMDD) is associated with increased likelihood of low back pain (LBP) and pain severity compared with skipped level disc degeneration (SLDD), according ...

Recommended for you

China lifts quarantine after man dies of plague

37 minutes ago

(AP)—A nine-day quarantine imposed on parts of a northern Chinese city where a man died of bubonic plague has been lifted, China's official news agency reported Thursday.

New device detects deadly lung disease

1 hour ago

A scientist from the University of Exeter has developed a simple, cheap and highly accurate device for diagnosing a frequently fatal lung disease which attacks immune deficient individuals such as cancer ...

User comments