Periodontitis linked to HPV-positive head, neck tumors
For patients with head and neck squamous cell carcinoma there is an increased risk of human papillomavirus-positive tumors among those with a history of periodontitis, according to a study published online June 18 in the Archives of Otolaryngology -- Head & Neck Surgery.
(HealthDay) -- For patients with head and neck squamous cell carcinoma (HNSCC) there is an increased risk of human papillomavirus (HPV)-positive tumors among those with a history of periodontitis, according to a study published online June 18 in the Archives of Otolaryngology -- Head & Neck Surgery.
Mine Tezal, D.D.S., Ph.D., from the State University of New York at Buffalo, and colleagues evaluated dental records and tissue samples from 124 patients over the age of 21 years diagnosed with incident primary squamous cell carcinoma (SCC) of the oral cavity, oropharynx, and larynx between 1999 and 2007. Alveolar bone loss measured from panoramic radiographs was used to assess periodontitis history, and the correlation between periodontitis and HPV status of HNSCC was evaluated.
The researchers found that the prevalence of HPV-positive HNSCC was 40.3 percent, with a higher proportion of oropharyngeal cancers HPV positive compared with oral cavity and laryngeal cancers (65.3 versus 29.0 and 20.5 percent, respectively). The odds of HPV-positive tumor status increased with each millimeter of alveolar bone loss (odds ratio [OR], 2.61), even after adjustment for age at diagnosis, sex, and smoking status. The odds of HPV-positive tumor status were greater among patients with oropharyngeal SCC (OR, 11.70), compared to those with oral cavity SCC (OR, 2.32; 95 percent confidence interval [CI], 0.65 to 8.27) and laryngeal SCC (OR, 3.89; 95 percent CI, 0.95 to 15.99).
"A history of chronic inflammatory disease in the oral cavity may be associated with tumor HPV status in patients with HNSCC," the authors write.
More information: Abstract
Full Text (subscription or payment may be required)
Copyright © 2012 HealthDay. All rights reserved.
- Study examines chronic inflammation in oral cavity and HPV status of head and neck cancers Jun 18, 2012 | not rated yet | 0
- Gender, insurance type tied to HPV infection in laryngeal cancer patients Sep 14, 2011 | not rated yet | 0
- HPV-positive head and neck cancer patients fare better than HPV-negative patients Feb 12, 2008 | not rated yet | 0
- Improved outcomes for HPV-positive head and neck cancer with cetuximab and IMRT Oct 25, 2010 | not rated yet | 0
- Oral HPV infection, HPV-related cancers more common in men Jan 26, 2012 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Why is zone 1 in liver more prone to ischemic injury?
18 hours ago Hi, Is it because around central vein, there is only deoxygenated blood from the vein where as in the periphery there is hepatic artery. Also why...
How can there be villous adenoma in colon, if there are no villi there
May 22, 2013 As title suggest. Thanks :smile:
How can there be a term called "intestinal metaplasia" of stomach
May 21, 2013 Hello everyone, Ok Stomach's normal epithelium is simple columnar, now in intestinal type of adenocarcinoma of stomach it undergoes "intestinal...
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
- More from Physics Forums - Medical Sciences
More news stories
Breast cancer characterized as "triple negative" carries a poor prognosis, with limited treatment options. In some cases, chemotherapy doesn't kill the cancer cells the way it's supposed to. New research from Western University ...
Cancer 5 hours ago | 5 / 5 (2) | 0
Mayo Clinic researchers have used next generation genomic analysis to determine that some of the more aggressive prostate cancer tumors have similar genetic origins, which may help in predicting cancer progression. The findings ...
Cancer 5 hours ago | not rated yet | 0
Even while being dragged to its destruction inside a cell, a cancer-promoting growth factor receptor fires away, sending signals that thwart the development of tumor-suppressing microRNAs (miRNAs) before it's dissolved, researchers ...
Cancer 6 hours ago | not rated yet | 0 |
Treating pediatric leukemia patients with a liposomal formulation of anthracycline-based chemotherapy at a more intense-than-standard dose during initial treatment may result in high survival rates without causing any added ...
Cancer 10 hours ago | not rated yet | 0
Scientists have uncovered a survival mechanism that occurs in breast cells that have just turned premalignant-cells on the cusp between normalcy and cancers-which may lead to new methods of stopping tumors.
Cancer 11 hours ago | not rated yet | 0 |
(Medical Xpress)—Regulating the distribution of power in neurons is done by a system that makes the national electric grid look simple by comparison. Each neuron has several thousand mitochondria confined ...
5 hours ago | 4.8 / 5 (5) | 0 |
Teams of highly respected Alzheimer's researchers failed to replicate what appeared to be breakthrough results for the treatment of this brain disease when they were published last year in the journal Science.
9 hours ago | 5 / 5 (1) | 2 |
A brief visual task can predict IQ, according to a new study. This surprisingly simple exercise measures the brain's unconscious ability to filter out visual movement. The study shows that individuals whose ...
11 hours ago | 4.9 / 5 (7) | 0 |
Scientists at the National Institutes of Health report they have discovered in mouse studies that a small molecule released in the spinal cord triggers a process that is later experienced in the brain as ...
9 hours ago | 5 / 5 (2) | 0 |
Little is known about why asthma develops, how it constricts the airway or why response to treatments varies between patients. Now, a team of researchers at Weill Cornell Medical College, Columbia University Medical Center ...
9 hours ago | not rated yet | 0 |
Ethnic background plays a surprisingly large role in how diabetes develops on a cellular level, according to two new studies led by researchers at the Stanford University School of Medicine.
7 hours ago | not rated yet | 0 |