Psoriasis increases risk of diabetes: study

Psoriasis is an independent risk for Type 2 Diabetes, according to a new study by researchers with the Perelman School of Medicine at the University of Pennsylvania, with the greatest risk seen in patients with severe psoriasis. Researchers estimate that an additional 115,500 people will develop diabetes each year due to the risk posed by psoriasis above and beyond conventional risk factors. The research is published in the latest issue of the Archives of Dermatology.

"These data suggest that patients with psoriasis are at increased risk for developing diabetes even if they don't have common risk factors such as obesity," said senior author Joel M. Gelfand, MD, MSCE, associate professor of Dermatology in the Perelman School of Medicine. "Patients with psoriasis should eat a healthy diet, get regular exercise, and see their physician for routine preventative health screenings such as checks of blood pressure, cholesterol, and blood sugar."

Psoriasis is a common inflammatory skin disease affecting over 7.5 million Americans and causes thick, inflamed, scaly patches of skin. The disease has previously been associated with increased risk of , stroke, and .

"This research builds on previous work demonstrating a diverse set of increased health risks for people with psoriasis," said lead author Rahat S. Azfar, MD, MSCE, adjunct assistant professor of Dermatology in the Perelman School of Medicine. "In addition to having an increased risk of diabetes, people with psoriasis are more likely to have metabolic syndrome, high triglycerides, and raised , even if they are not overweight or have other common risk factors for these conditions. Both patients with psoriasis, especially those with severe psoriasis, and their treating physicians should be aware of the potential for systemic associated with this skin disease."

Both psoriasis and diabetes are diseases caused by . A shared pathway - TH-1 cytokines - can promote insulin resistance and metabolic syndrome, and promote inflammatory cytokines known to drive psoriasis.

The study compared 108,132 people with psoriasis to 430,716 matched patients without psoriasis, and determined patients with mild psoriasis had an 11% increased risk of diabetes and patients with severe psoriasis had a 46% higher risk compared to patients without psoriasis. The study also looked at treatments used by those diagnosed with diabetes, and found that the patients with both psoriasis and diabetes were more likely to require pharmacological treatment of diabetes, compared to diabetics without psoriasis.

Researchers noted that future studies should look into the extent to which psoriasis and its treatment play a role in the development of and its complications.

More information: Arch Dermatol. Published online June 18, 2012. doi:10.1001/archdermatol.2012.1401

Related Stories

Recommended for you

Recorded Ebola deaths top 7,000

20 hours ago

The worst Ebola outbreak on record has now killed more than 7,000 people, with many of the latest deaths reported in Sierra Leone, the World Health Organization said as United Nations Secretary-General Ban ...

Liberia holds Senate vote amid Ebola fears (Update)

Dec 20, 2014

Health workers manned polling stations across Liberia on Saturday as voters cast their ballots in a twice-delayed Senate election that has been criticized for its potential to spread the deadly Ebola disease.

Evidence-based recs issued for systemic care in psoriasis

Dec 19, 2014

(HealthDay)—For appropriately selected patients with psoriasis, combining biologics with other systemic treatments, including phototherapy, oral medications, or other biologic, may result in greater efficacy ...

Bacteria in caramel apples kills at least four in US

Dec 19, 2014

A listeria outbreak believed to originate from commercially packaged caramel apples has killed at least four people in the United States and sickened 28 people since November, officials said Friday.

Steroid-based treatment may answer needs of pediatric EoE patients

Dec 19, 2014

A new formulation of oral budesonide suspension, a steroid-based treatment, is safe and effective in treating pediatric patients with eosinophilic esophagitis (EoE), according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal ...

User comments

Adjust slider to filter visible comments by rank

Display comments: newest first

joemostowey
not rated yet Jun 18, 2012
Dumkoffs!
Look at the gut bacteria! Look! Look! Bacteria are know to mimic neurotansmitters, which cause inflamation throughout the entire body. Both psoriasis and diabetes are results of a compromised immune system attacking the body itself due to the effect of these bogus neurotransmitters. Much of the guts' native bacteria are killed by the use of general antibiotics proscribed to cure something else. Some of the same bacteria that inhabits the mouth and gums are taking up residence in the gut, and in the cardiovascular system causing inflamation in the vessel walls as well as in the intestines- and without the native bateria to run interference (competition) they attempt to alter the host body to make it more hospitable for them.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.