New, combined equation more accurately estimates GFR

New, combined equation more accurately estimates GFR
A combined creatinine-cystatin C equation has improved performance and accuracy for estimating glomerular filtration rate, according to research published in the July 5 issue of the New England Journal of Medicine.

(HealthDay) -- A combined creatinine-cystatin C equation has improved performance and accuracy for estimating glomerular filtration rate (GFR), according to research published in the July 5 issue of the New England Journal of Medicine.

Using data from 13 studies involving 5,352 participants, Lesley A. Inker, M.D., from Tufts Medical Center in Boston, and colleagues developed estimating equations based on alone and in combination with creatinine. Validation of the equations was performed in 1,119 participants from five different studies in which GFR had been measured.

In the validation set, the researchers found that the creatinine-cystatin C equation performed better than equations that used creatinine or cystatin C alone. among the three equations was similar. The combined equation had significantly improved precision (interquartile range of the difference, 13.4 versus 15.4 and 16.4 ml/min/1.73 m², respectively) and accuracy (percentage of estimates that were >30 percent of measured GFR, 8.5 versus 12.8 and 14.1, respectively). For participants with a creatinine-based estimated GFR of 45 to 74 ml/min/1.73 m², the combined equation improved classification (net reclassification index, 19.4 percent) and correctly reclassified 16.9 percent of patients with a creatinine-based estimated GFR of 45 to 59 ml/min/1.73 m² to ≥60 ml/min/1.73 m².

"The combination of serum and serum cystatin C is more accurate than either marker alone for estimating GFR," the authors write. "The new equations represent an advance over currently available equations across the range of GFR and in relevant subgroups."

Two study authors and the editorial author disclosed financial ties to the pharmaceutical and biotechnology industries.

More information: Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Study finds a better method for diagnosing kidney disease

date May 08, 2012

Assessing glomerular filtration rate (GFR) using kidney filtration markers in blood is the standard means for determining kidney function, diagnosing kidney disease and measuring its progression. A higher filtration rate ...

Post-transplant, eGFR impacts cardio risk independently

date May 30, 2012

(HealthDay) -- In stable kidney transplant recipients, kidney function, as determined by estimated glomerular filtration rate (eGFR), is independently associated with cardiovascular (CVD) events and death, ...

Recommended for you

Dengue cases soar in Brazil, as death toll climbs

date 3 hours ago

Cases of dengue have soared in Brazil where the disease has caused 229 fatalities this year, the Health Ministry said Monday, as authorities try to combat its spread using transgenic mosquitos.

Meningitis epidemic kills more than 250 in Niger

date 5 hours ago

A meningitis epidemic in poverty-stricken Niger has claimed 252 lives since January, a health official said Monday, warning the country was short of vaccines to fight the outbreak.

New hope for short bowel syndrome

date 11 hours ago

Researchers at Children's Hospital Los Angeles have successfully made a small intestine that has the structural and molecular components of a healthy intestine.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.