New, combined equation more accurately estimates GFR

July 6, 2012
New, combined equation more accurately estimates GFR
A combined creatinine-cystatin C equation has improved performance and accuracy for estimating glomerular filtration rate, according to research published in the July 5 issue of the New England Journal of Medicine.

(HealthDay) -- A combined creatinine-cystatin C equation has improved performance and accuracy for estimating glomerular filtration rate (GFR), according to research published in the July 5 issue of the New England Journal of Medicine.

Using data from 13 studies involving 5,352 participants, Lesley A. Inker, M.D., from Tufts Medical Center in Boston, and colleagues developed estimating equations based on alone and in combination with creatinine. Validation of the equations was performed in 1,119 participants from five different studies in which GFR had been measured.

In the validation set, the researchers found that the creatinine-cystatin C equation performed better than equations that used creatinine or cystatin C alone. among the three equations was similar. The combined equation had significantly improved precision (interquartile range of the difference, 13.4 versus 15.4 and 16.4 ml/min/1.73 m², respectively) and accuracy (percentage of estimates that were >30 percent of measured GFR, 8.5 versus 12.8 and 14.1, respectively). For participants with a creatinine-based estimated GFR of 45 to 74 ml/min/1.73 m², the combined equation improved classification (net reclassification index, 19.4 percent) and correctly reclassified 16.9 percent of patients with a creatinine-based estimated GFR of 45 to 59 ml/min/1.73 m² to ≥60 ml/min/1.73 m².

"The combination of serum and serum cystatin C is more accurate than either marker alone for estimating GFR," the authors write. "The new equations represent an advance over currently available equations across the range of GFR and in relevant subgroups."

Two study authors and the editorial author disclosed financial ties to the pharmaceutical and biotechnology industries.

More information: Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Study finds a better method for diagnosing kidney disease

May 8, 2012

Assessing glomerular filtration rate (GFR) using kidney filtration markers in blood is the standard means for determining kidney function, diagnosing kidney disease and measuring its progression. A higher filtration rate ...

Post-transplant, eGFR impacts cardio risk independently

May 30, 2012

(HealthDay) -- In stable kidney transplant recipients, kidney function, as determined by estimated glomerular filtration rate (eGFR), is independently associated with cardiovascular (CVD) events and death, according to research ...

Recommended for you

Experimental MERS vaccine shows promise in animal studies

July 28, 2015

A two-step regimen of experimental vaccines against Middle East respiratory syndrome (MERS) prompted immune responses in mice and rhesus macaques, report National Institutes of Health scientists who designed the vaccines. ...

Can social isolation fuel epidemics?

July 21, 2015

Conventional wisdom has it that the more people stay within their own social groups and avoid others, the less likely it is small disease outbreaks turn into full-blown epidemics. But the conventional wisdom is wrong, according ...

Lack of knowledge on animal disease leaves humans at risk

July 20, 2015

Researchers from the University of Sydney have painted the most detailed picture to date of major infectious diseases shared between wildlife and livestock, and found a huge gap in knowledge about diseases which could spread ...

IBD genetically similar in Europeans and non-Europeans

July 20, 2015

The first genetic study of inflammatory bowel disease (IBD) to include individuals from diverse populations has shown that the regions of the genome underlying the disease are consistent around the world. This study, conducted ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.