Researchers find new target deep within cancer cells
Investigators reporting in the July issue of the journal Cancer Cell have found that blocking a fundamental process deep within cancer cells can selectively kill them and spare normal cells.
For more than a century, clinicians have known that abnormalities of the nucleolusa small, rounded mass within the cell nucleuscan be diagnostic for cancer. The nucleolus is where certain genes are read to form the components of ribosomes, the cellular machines that make proteins. While abnormalities in the nucleolus are known to be diagnostic for cancer, researchers have wondered whether they are required for cells to become malignant.
Now investigators have provided definitive evidence that accelerated reading of ribosomal genes is responsible for causing abnormal nucleoli and is necessary for the survival of cancer cells. They also show that blocking this accelerated reading in mice can set off a cascade of events that cause lymphoma and leukemia cells to die while sparing normal cells.
"The work in this study demonstrates that cancer cells are far more dependent on their ability to make ribosomes than normal cells. Critically, we demonstrate that selective inhibition of the enzyme, RNA polymerase I, that's responsible for synthesizing the major ribosomal components can be used to selectively kill cancer cells while leaving normal cells untouched," says senior author Dr. Ross Hannan, of the Peter MacCallum Cancer Centre in Australia. Previously, it was assumed that the ability to make ribosomes would be equally important to normal and cancer cells.
The findings suggest that selective inhibitors of RNA polymerase I may be effective therapeutics for the treatment of human cancers. Based on the findings in this study, investigators will study one such inhibitor, Cylene Pharmaceuticals' CX-5461, in clinical trials at the Peter MacCallum Cancer Centre later this year.
More information: Bywater et al.: "Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53." Cancer Cell. dx.doi.org/10.1016… .2012.05.019
Journal reference: Cancer Cell
Provided by Cell Press
- Anti-cancer virus kills brain cancer cells Nov 01, 2006 | not rated yet | 0
- Scientists can now differentiate between healthy cells and cancer cells Jan 05, 2009 | not rated yet | 0
- Study: How some cancers become leukemia Jul 17, 2006 | not rated yet | 0
- Dundee researchers make gene breakthrough Sep 16, 2011 | not rated yet | 0
- Research identifies how cancer cells cheat death Jun 08, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
How can there be a term called "intestinal metaplasia" of stomach
21 hours ago Hello everyone, Ok Stomach's normal epithelium is simple columnar, now in intestinal type of adenocarcinoma of stomach it undergoes "intestinal...
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013 As an experiment, for the past few months I've been consuming at least one portion of Jell-O or unflavored Knox gelatin per day. I'm 64, in very...
Alcohol and acetaminophen
May 13, 2013 Edit: sorry for the typo in the title , can't edit I looked around on google quite a bit and it's very hard to find precise information on the...
- More from Physics Forums - Medical Sciences
More news stories
The gap between life expectancy in patients with a mental illness and the general population has widened since 1985 and efforts to reduce this gap should focus on improving physical health, suggest researchers in a paper ...
Cancer 9 hours ago | not rated yet | 0
By studying the roles two proteins, thrombospondin-1 and prosaposin, play in discouraging cancer metastasis, a trans-Atlantic research team has identified a five-amino acid fragment of prosaposin that significantly reduces ...
Cancer 10 hours ago | not rated yet | 0
A novel transcriptome-based classification of colon cancer that improves the current disease stratification based on clinicopathological variables and common DNA markers is presented in a study published in PLOS Medicine this w ...
Cancer 11 hours ago | not rated yet | 0
A study of veterans at high risk for developing lung cancer shows that low-dose computed tomography (LDCT) can be highly effective in helping clinicians spot tiny lung nodules which, in a small number of patients, may indicate ...
Cancer 12 hours ago | not rated yet | 0
An attack on glioblastoma brain tumor cells that uses a modified poliovirus is showing encouraging results in an early study to establish the proper dose level, researchers at Duke Cancer Institute report.
Cancer 14 hours ago | not rated yet | 0
Phthalates: Study links chemicals widely found in plastics, processed food to elevated blood pressure in children, teens
Plastic additives known as phthalates (pronounced THAL-ates) are odorless, colorless and just about everywhere: They turn up in flooring, plastic cups, beach balls, plastic wrap, intravenous tubing and—according to the ...
7 minutes ago | not rated yet | 0 |
(Medical Xpress)—Native peoples in regions where cameras are uncommon sometimes react with caution when their picture is taken. The fear that something must have been stolen from them to create the photo ...
16 hours ago | 4.2 / 5 (5) | 0 |
(Medical Xpress)—Despite spending billions of dollars on research and development, drug companies have been unable to come up with effective treatments for dementia and Alzheimer's Disease (AD). Now, A. ...
14 hours ago | 4.9 / 5 (13) | 0 |
Australian scientists have charted the path of insulin action in cells in precise detail like never before. This provides a comprehensive blueprint for understanding what goes wrong in diabetes.
16 hours ago | 4.6 / 5 (7) | 0 |
An experimental sleeping pill from US drug company Merck is effective at helping people fall and stay asleep, according to reviewers at the US Food and Drug Administration, which could soon approve the new drug.
10 hours ago | 4 / 5 (4) | 0
Activating an enzyme known to play a role in the anti-aging benefits of calorie restriction delays the loss of brain cells and preserves cognitive function in mice, according to a study published in the May ...
11 hours ago | 5 / 5 (4) | 0 |