Drug shows promise for triple-negative breast cancer

Tulane scientists, led by Dr. Bridgette Collins-Burow, have reported research results of a promising new therapy for triple-negative breast cancer. (Photo by Paula Burch-Celentano)

(Medical Xpress) -- A promising new therapy for hard-to-treat triple-negative breast cancer has been reported in the journal Breast Cancer Research by a team at the Tulane University School of Medicine, led by Dr. Bridgette Collins-Burow.

More than one million cases of are diagnosed worldwide every year, of which approximately 15 percent are triple-negative cancers, according to the team that reported on the study.

“Lack of effective therapies, young age at the onset of the disease and early metastatic spread have contributed to the poor prognoses and outcomes associated with these malignancies,” says Collins-Burow, an assistant professor of medicine.

Some kinds of breast cancer can be treated with drugs that target hormone receptors, which are protein structures on and inside cells. In healthy cells and most kinds of cancer cells, hormones attach to such receptors and provide signals to the cells for growth and functioning.

These cancers can be treated by hormonal therapies — drugs that bind to the receptors in place of hormones, thus cutting off hormonal signaling and eventually killing the cells.

But triple-negative breast cancers lack these hormone receptors, so the cancer cells continue to flourish. Triple-negative cancers also lack the growth factor receptor HER2 and cannot be treated with monoclonal therapy such as Herceptin. 


The Tulane team explored the effect of using a histone deacetylase (HDAC) inhibitor called panobinostat on triple-negative breast cancer tumors in mice. This drug inhibits the actions of rogue enzymes that are responsible for allowing the uncontrolled growth of cancer cells. 


“Panobinostat selectively targeted triple-negative breast and decreased tumor growth in mice,” says Collins-Burow. “It was also able to partially reverse the morphological changes in cells to a more epithelial type. These results show a potential therapeutic role for HDAC inhibitors, especially panobinostat, in targeting the aggressive triple-negative breast cancer.”

More information: breast-cancer-research.com/content/14/3/R79

Related Stories

Trio of drugs may combat 'triple negative' breast cancer

Dec 10, 2010

A gene target for drug resistance, a triple-drug cocktail for triple negative breast cancer, and patients' risk for carpal tunnel syndrome are among study highlights scheduled to be presented by Johns Hopkins Kimmel Cancer ...

Recommended for you

Putting the brakes on cancer

9 hours ago

A study led by the University of Dundee, in collaboration with researchers at our University, has uncovered an important role played by a tumour suppressor gene, helping scientists to better understand how ...

Peanut component linked to cancer spread

10 hours ago

Scientists at the University of Liverpool have found that a component of peanuts could encourage the spread and survival of cancer cells in the body.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.