Three SNPs linked to aortic stenosis in older adults

Three SNPs linked to aortic stenosis in older adults
Three single nucleotide polymorphisms are associated with aortic stenosis involving tricuspid aortic valves in older patients, according to a study published in the July 1 issue of The American Journal of Cardiology.

(HealthDay) -- Three single nucleotide polymorphisms (SNPs) are associated with aortic stenosis involving tricuspid aortic valves in older patients, according to a study published in the July 1 issue of The American Journal of Cardiology.

Stephen G. Ellis, M.D., from the Cleveland Clinic, and colleagues genotyped 265 patients (aged 73 ± 7 years; 72.7 percent male) with aortic stenosis involving tricuspid and 961 controls (69 ± 6 years; 69.8 percent male) for up to 660 candidate . The correlation between age-adjusted aortic valve area, as determined by echocardiography or cardiac catheterization, and SNPs was assessed, with a bootstrapped global P value of ≤0.005 indicative of a possible significant correlation.

The researchers found that minor allele frequency was 21 percent ± 15 percent. The criteria for a significant correlation were met by three SNPs (rs2276288 [MYO7A], P = 0.001; rs5194 [AGTR1], P = 0.004; rs207 307 [ELN], P = 0.005). Two additional SNPs achieved borderline significance (P ≤0.008).

"In conclusion, we report three SNPs to be associated with aortic stenosis involving tricuspid aortic valves in older subjects," the authors write. "Given the concerns regarding the problem of multiple statistical testing, validation studies are required to further assess these correlations."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

'Healthy' sterols may pose health risk

Jul 14, 2008

Plant sterols have been touted as an effective way to lower cholesterol and reduce the risk of heart disease. However, a research study in the July JLR has uncovered that these compounds do have their own risks, as they can ...

Inflammation behind heart valve disease

Mar 15, 2011

Research from Karolinska Institutet in Sweden shows, that a specific inflammatory factor may be important in the development of the heart valve disease aortic stenosis. The results suggest that anti-inflammatory medication ...

Recommended for you

'Face time' for the heart diagnoses cardiac disease

2 hours ago

To the careful observer, a person's face has long provided insight into what is going on beneath the surface. Now, with the assistance of a web camera and software algorithms, the face can also reveal whether or not an individual ...

Pay-for-performance not found to impact access to CABG

Aug 27, 2014

(HealthDay)—For patients with acute myocardial infarction (AMI), treatment at pay-for-performance (P4P) hospitals is not associated with a change in the rate of coronary artery bypass graft (CABG) surgery, ...

User comments

Adjust slider to filter visible comments by rank

Display comments: newest first

nanotech_republika_pl
not rated yet Jul 06, 2012
23andme ver. 3 chip provides information about 2 of those listed SNPs.