In type 2 DM, proteinuria with SBP <130 ups CVD mortality

In type 2 DM, proteinuria with SBP &#60;130 ups CVD mortality
Patients with type 2 diabetes, proteinuria, and systolic blood pressure (BP) <130 mm Hg are at an increased risk of total and cardiovascular disease (CVD) mortality, suggesting that proteinuria should be taken into account when establishing target systolic BP levels for prevention of fatal CVD events, according to research published online Aug. 14 in the Journal of Internal Medicine.

(HealthDay)—Patients with type 2 diabetes, proteinuria, and systolic blood pressure (BP) <130 mm Hg are at an increased risk of total and cardiovascular disease (CVD) mortality, suggesting that proteinuria should be taken into account when establishing target systolic BP levels for prevention of fatal CVD events, according to research published online Aug. 14 in the Journal of Internal Medicine.

In an effort to determine the interaction between BP and on total and CVD mortality, Teemu Vepsäläinen, M.D., of the University of Turku in Finland, and colleagues conducted a prospective, population-based study involving 881 middle-aged patients with poorly controlled type 2 diabetes without CVD who were followed for as long as 18 years. Patients were grouped according to systolic BP (<130, 130 to 139, 140 to 159, ≥160 mm Hg) and by presence or absence of proteinuria (≤150 or >150 mg/L).

The researchers found that, overall, 68.9 percent of patients died during follow-up, including 44.8 percent due to CVD. Patients with proteinuria and systolic BP <130 mm Hg had an approximately two-fold higher total and CVD mortality than those with systolic BP between 130 and 139 mm Hg, and a 1.6-fold higher total and CVD mortality than those with systolic BP of 140 to 159 mm Hg.

"To our knowledge, this is the first large population-based long-term follow-up study to investigate the impact of systolic BP on total and CVD mortality in patients with with and without proteinuria," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Swimming improves vascular function, BP in older adults

Mar 30, 2012

(HealthDay) -- Swimming exercise is associated with a decrease in blood pressure (BP) and improvements in vascular function in older adults with early hypertension, according to a study published in the April ...

Recommended for you

Ebola death toll passes 7,500

3 hours ago

More than 7,500 people have now died from the Ebola virus, as the number of cases climbs towards 20,000, the World Health Organization said Monday.

Ebola-infected Italian doctor 'recovering'

3 hours ago

An Italian doctor who contracted Ebola in west Africa is recovering but is still in an isolation unit, the specialist clinic in Rome treating him said Monday.

Restrictions lifted at British bird flu farm

Dec 21, 2014

Britain on Sunday lifted all restrictions at a duck farm in northern England after last month's outbreak of H5N8 bird flu, the same strain seen in recent cases across Europe.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.