Study shows long-term effects of radiation in pediatric cancer patients
For many pediatric cancer patients, total body irradiation (TBI) is a necessary part of treatment during bone marrow transplant it's a key component of long term survival. But lengthened survival creates the ability to notice long term effects of radiation as these youngest cancer patients age. A University of Colorado Cancer Center study recently published in the journal Pediatric Blood & Cancer details these late effects of radiation.
"These kids basically lie on a table and truly do get radiation from head to toe. There is a little blocking of the lungs, but nothing of, for example, the brain or the kidneys," says Jean Mulcahy-Levy, MD, research fellow at the CU Cancer Center and the paper's first author.
Of 15 patients who received TBI before age 3, many developed endocrine and metabolic problems including testicular malfunction (78 percent), restrictive pulmonary disease due to high levels of blood triglycerides (74 percent), and cataracts (78 percent). Likewise, 90 percent of patients showed abnormally low levels of growth hormone, and 71 percent were considerably under height. Additional late effects of TBI included kidney, liver, skeletal and cardiac malfunction and three of four patients whose IQ had been tested before TBI showed cognitive decline.
"Fifteen doesn't seem like a large number, but because we have such a good pediatric bone marrow transplant program here at Children's Hospital Colorado and radiation therapy program at the CU Cancer Center, we were able to get a large enough cohort of patients to see these overall effects," Mulcahy-Levy says.
The study supports the recommendations of the Children's Oncology Group for long term follow up care for children receiving TBI (survivorshipguidelines.org). Specifically, Mulcahy-Levy hopes that increasing awareness of likely effects will help patients and their doctors screen for, detect, and correct likely effects of TBI.
"It's not so much that you want to stop TBI, which is frequently a necessary part of treatment, but this study shows it's important know about these problems in order to address them appropriately and proactively," Mulcahy-Levy says.
Provided by University of Colorado Denver
- Stem cells may provide treatment for brain injuries Mar 10, 2011 | not rated yet | 0
- Single traumatic brain injury may prompt long-term neurodegeneration Jul 18, 2011 | not rated yet | 0
- Traumatic brain injury shows strong link to depression, but treatments lack study Apr 14, 2011 | not rated yet | 0
- Radiation plus chemotherapy provides long-term positive results for head and neck cancer patients Jan 26, 2012 | not rated yet | 0
- Study finds headaches after traumatic brain injury highest in adolescents and girls Dec 05, 2011 | not rated yet | 0
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013 As an experiment, for the past few months I've been consuming at least one portion of Jell-O or unflavored Knox gelatin per day. I'm 64, in very...
Alcohol and acetaminophen
May 13, 2013 Edit: sorry for the typo in the title , can't edit I looked around on google quite a bit and it's very hard to find precise information on the...
Marie Curie's leukemia
May 13, 2013 Does anyone know what might be the cause of Marie Curie's cancer
- More from Physics Forums - Medical Sciences
More news stories
Older prostate cancer patients with other underlying health conditions should think twice before committing to surgery or radiation therapy for their cancer, according to a multicenter study led by researchers in the UCLA ...
Cancer 10 hours ago | not rated yet | 0 |
Intensity-modulated radiation therapy has become the most commonly used type of radiation in prostate cancer, but research from the University of North Carolina suggests that the therapy may not be more effective than older, ...
Cancer 12 hours ago | not rated yet | 0
Cancer 13 hours ago | 4.8 / 5 (12) | 2 |
(HealthDay)—For young adults needing either a chest or abdominopelvic computed tomography (CT), the short-term risk of death from underlying morbidity is greater than the long-term risk of radiation-induced ...
Cancer 14 hours ago | not rated yet | 0
In a new study described in the journal Oncogene, researchers reveal how a key player in cell growth, immunity and the inflammatory response can be transformed into a primary contributor to tumor growth.
Cancer 19 hours ago | not rated yet | 0 |
44 minutes ago | not rated yet | 0 |
44 minutes ago | not rated yet | 0
27 minutes ago | not rated yet | 0
10 hours ago | 4.6 / 5 (13) | 4 |
Early-life exposure to traffic-related air pollution was significantly associated with higher hyperactivity scores at age 7, according to new research from the University of Cincinnati (UC) and Cincinnati Children's Hospital ...
4 hours ago | not rated yet | 0 |
Salamanders' immune systems are key to their remarkable ability to regrow limbs, and could also underpin their ability to regenerate spinal cords, brain tissue and even parts of their hearts, scientists have ...
13 hours ago | 4.8 / 5 (6) | 2 |