Stress causes lower INR in VTE patients not on blood thinners

August 26, 2012
Stress causes lower INR in VTE patients not on blood thinners
The effect of psychological distress on clotting times and clotting factors varies in patients with venous thromboembolism and depends on whether or not they are receiving oral anticoagulant therapy, according to a Swiss study published in the August issue of the Journal of Thrombosis and Haemostasis.

(HealthDay)—The effect of psychological distress on clotting times and clotting factors varies in patients with venous thromboembolism (VTE) and depends on whether or not they are receiving oral anticoagulant (OAC) therapy, according to a Swiss study published in the August issue of the Journal of Thrombosis and Haemostasis.

Roland Von Känel, M.D., of the Bern University Hospital in Switzerland, and associates analyzed 190 with previous VTE to evaluate the effect of psychological distress on the international normalized ratio (INR) and clotting factors of the extrinsic pathway with (42 patients) and without (148 patients) OAC therapy.

The researchers found that the odds of a reduced INR (<1.00) were significantly increased by one standard deviation for symptoms of depression, anxiety, worry, and anger, after normal adjustments in VTE patients without OAC therapy. INR was found to be unrelated to a negative affect in patients with OAC therapy; these patients also showed lower levels of clotting factors.

"Psychological distress was associated with a reduced INR in VTE patients without OAC therapy," the authors write. "The direction of the association between and activity in some clotting factors of the extrinsic coagulation pathway might differ depending on whether VTE patients are under OAC therapy or not."

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Venous thromboembolism up in adult hospitalizations

June 8, 2012

(HealthDay) -- Every year, more than half a million hospitalized U.S. adults acquire venous thromboembolism (VTE), a growing public health concern that is often preventable, according to research published in the June 8 issue ...

Higher risk of VTE in CKD surgical patients on enoxaparin

June 8, 2012

(HealthDay) -- For patients with chronic kidney disease (CKD) who undergo total hip replacement (THR), the rate of major venous thromboembolism (VTE) is significantly higher in those treated with enoxaparin compared to those ...

Long-term mortality risk low after cerebral vein thrombosis

July 12, 2012

(HealthDay) -- For patients who survive a cerebral vein thrombosis (CVT), the long-term risk of mortality and recurrent venous thromboembolism (VTE) seems to be low, according to a study published in the July issue of the ...

Unsuspected PE does not up mortality risk in cancer patients

August 6, 2012

(HealthDay) -- Cancer patients with an unsuspected pulmonary embolism (UPE) do not have an increased mortality risk and have a similar risk of recurrent venous thromboembolism (VTE) to those with clinically suspected pulmonary ...

Recommended for you

Experimental MERS vaccine shows promise in animal studies

July 28, 2015

A two-step regimen of experimental vaccines against Middle East respiratory syndrome (MERS) prompted immune responses in mice and rhesus macaques, report National Institutes of Health scientists who designed the vaccines. ...

Can social isolation fuel epidemics?

July 21, 2015

Conventional wisdom has it that the more people stay within their own social groups and avoid others, the less likely it is small disease outbreaks turn into full-blown epidemics. But the conventional wisdom is wrong, according ...

Lack of knowledge on animal disease leaves humans at risk

July 20, 2015

Researchers from the University of Sydney have painted the most detailed picture to date of major infectious diseases shared between wildlife and livestock, and found a huge gap in knowledge about diseases which could spread ...

IBD genetically similar in Europeans and non-Europeans

July 20, 2015

The first genetic study of inflammatory bowel disease (IBD) to include individuals from diverse populations has shown that the regions of the genome underlying the disease are consistent around the world. This study, conducted ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.