Stress causes lower INR in VTE patients not on blood thinners

Stress causes lower INR in VTE patients not on blood thinners
The effect of psychological distress on clotting times and clotting factors varies in patients with venous thromboembolism and depends on whether or not they are receiving oral anticoagulant therapy, according to a Swiss study published in the August issue of the Journal of Thrombosis and Haemostasis.

(HealthDay)—The effect of psychological distress on clotting times and clotting factors varies in patients with venous thromboembolism (VTE) and depends on whether or not they are receiving oral anticoagulant (OAC) therapy, according to a Swiss study published in the August issue of the Journal of Thrombosis and Haemostasis.

Roland Von Känel, M.D., of the Bern University Hospital in Switzerland, and associates analyzed 190 with previous VTE to evaluate the effect of psychological distress on the international normalized ratio (INR) and clotting factors of the extrinsic pathway with (42 patients) and without (148 patients) OAC therapy.

The researchers found that the odds of a reduced INR (<1.00) were significantly increased by one standard deviation for symptoms of depression, anxiety, worry, and anger, after normal adjustments in VTE patients without OAC therapy. INR was found to be unrelated to a negative affect in patients with OAC therapy; these patients also showed lower levels of clotting factors.

"Psychological distress was associated with a reduced INR in VTE patients without OAC therapy," the authors write. "The direction of the association between and activity in some clotting factors of the extrinsic coagulation pathway might differ depending on whether VTE patients are under OAC therapy or not."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Africans worst responders in Ebola crisis

1 minute ago

The head of Africa's continental body did not get to an Ebola-hit country until last week—months after alarm bells first rang and nearly 5,000 deaths later.

Mediterranean diet may help protect kidney health

13 hours ago

Adhering to a Mediterranean-style diet may significantly reduce the risk of developing chronic kidney disease, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (C ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.