Infections in rheumatoid arthritis patients—study finds way to pinpoint risk

Rheumatoid arthritis alone is painful and disabling, but it also puts patients at higher risk of death. The greater susceptibility to infections that accompanies the autoimmune disorder is one reason. Assessing the danger of infection a particular patient faces so it can be addressed can prove challenging for physicians. A Mayo Clinic study finds that a risk score can be developed to predict a patient's chances of having serious infections. The score uses information about how rheumatoid arthritis is affecting a patient, plus factors including age, corticosteroid use and the presence of other illnesses.

The findings are published online in the journal & Rheumatism.

Using the National Institutes of Health-funded Rochester Epidemiology Project, researchers studied medical records of 584 rheumatoid arthritis patients diagnosed between 1955 and 1994 and followed up on until January 2000. Of those, 252, or nearly half, had more than one serious infection requiring hospitalization and/or intravenous antibiotic; those 252 collectively racked up 646 infections.

The Mayo team developed an infection risk score based on those and other rheumatoid arthritis patients they studied. Factors in the calculation include age; previous serious infections; corticosteroid use; a low white blood cell count; elevated results in a blood test used to detect signs of inflammation, called an erythrocyte sedimentation rate; signs of rheumatoid arthritis outside joints; and the presence of other serious conditions such as heart disease, heart failure, diabetes, lung disease, vascular disease and alcoholism. They confirmed the usefulness of the risk score in a second group of patients with rheumatoid arthritis from the same population.

"Using a in this way can alert physicians that their patient is at high risk for infection and needs more frequent follow-ups, measures for infection prevention and possible changes in treatments," says senior author Eric Matteson, M.D., chair of the Division of Rheumatology at Mayo Clinic.

"Rheumatoid arthritis patients are at higher risk of infection, and that risk is clearly not just because of the arthritis drugs."

More research is needed to determine the level of infection risk at which patients get the most benefit from medications to prevent infection and how infection risk might affect use of a category of drugs called disease-modifying antirheumatic drugs, or DMARDs, such as biologics, the study says.

add to favorites email to friend print save as pdf

Related Stories

Infection risk up for seniors with rheumatoid arthritis

Aug 07, 2012

(HealthDay) -- Elderly adults with rheumatoid arthritis have a considerable risk of serious infection, with antirheumatic drug use increasing the risk, according to a study published online July 25 in Arthritis Ca ...

Lower GI problems plague many with rheumatoid arthritis

Apr 03, 2012

Add lower gastrointestinal (GI) problems such as ulcers, bleeding and perforations to the list of serious complications facing many rheumatoid arthritis patients. They are at greater risk for GI problems and gastrointestinal-related ...

Recommended for you

Mummy remains refute antiquity of ankylosing spondylitis

Oct 20, 2014

Ankylosing spondylitis is a systemic disease that causes inflammation in the spinal joints and was thought to have affected members of the ancient Egyptian royal families. Now a new study published in Arthritis & Rheumatology, a jour ...

Arthritis sufferers excluded from everyday life

Oct 13, 2014

Arthritis is the second leading cause of disability in Australia with many sufferers so severely disabled they cannot engage in basic everyday activities, new UNSW research has found.

User comments

Adjust slider to filter visible comments by rank

Display comments: newest first

MyPerfectBones_com
not rated yet Sep 10, 2012
Feed and nourish bones, joints and articular cartilage, and reduce pain with all natural supplements like My Perfect Joints (google it...)