White matter structural changes ID'd in children with T1DM

September 17, 2012
White matter structural changes ID'd in children with T1DM
Children with type 1 diabetes have significant structural differences in the white matter of their brain compared to healthy children, which correlates with hemoglobin A1c values, according to a study published online Sept. 10 in Diabetes Care.

(HealthDay)—Children with type 1 diabetes have significant structural differences in the white matter of their brain compared to healthy children, which correlates with hemoglobin A1c (HbA1c) values, according to a study published online Sept. 10 in Diabetes Care.

To examine clinical correlates of cognitive abilities and white matter microstructural changes in young children with diabetes, Tandy Aye, M.D., from the Stanford University School of Medicine in California, and colleagues used (DTI) scans and neurocognitive testing from 22 children (ages 3 to 10 years) with type 1 diabetes and 14 matched, healthy controls.

The researchers found that children with type 1 diabetes had significantly lower axial diffusivity (AD) values in the temporal and parietal lobe regions, compared with healthy controls. For fractional anisotropy and radial diffusivity (RD) there were no significant differences between the groups. There was a significant, positive correlation between time-weighted HbA1c and RD within the diabetes group. A higher, time-weighted HbA1c value also correlated with reduced overall intellectual functioning.

"Children with had significantly different white matter structure (as measured by AD) when compared with controls," the authors write. "In addition, white matter structural differences (as measured by RD) were significantly correlated with their HbA1c values."

Explore further: Study assesses glucose monitoring trends in tweens

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Study assesses glucose monitoring trends in tweens

April 12, 2012

(HealthDay) -- During the transition to adolescence, children with type 1 diabetes monitor their blood glucose less frequently, resulting in significant increases in HbA1c levels, according to research published online April ...

Isomaltulose doesn't improve glycemic control in diabetes

April 13, 2012

(HealthDay) -- For patients with type 2 diabetes, substitution of sucrose with isomaltulose is not associated with improved glycemic control (measured by hemoglobin A1c [HbA1c] levels) at 12 weeks, according to a study published ...

White matter of abstinent alcoholics recovers over time

May 21, 2012

(HealthDay) -- Based on diffusion tensor imaging (DTI), the microstructural changes seen in the genu and body of the corpus callosum in recently detoxified alcohol-dependent patients are found to improve after one year of ...

Sleep apnea severity linked to glycated hemoglobin levels

June 18, 2012

(HealthDay) -- For adults without diabetes, obstructive sleep apnea (OSA) severity is independently associated with impaired glucose metabolism, as measured by glycated hemoglobin (HbA1c) levels, according to a study published ...

Recommended for you

Electric fields weaker in slow-healing diabetic wounds

June 16, 2016

People with diabetes often suffer from wounds that are slow to heal and can lead to ulcers, gangrene and amputation. New research from an international group led by Min Zhao, professor of ophthalmology and of dermatology ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.