Monoclonal antibody effective therapy for diabetic retinopathy

October 7, 2012
Monoclonal antibody effective therapy for diabetic retinopathy
An antibody can reduce retinal vascular leakage and inflammation in rat models of diabetic retinopathy, according to a study published online Oct. 1 in Diabetes.

(HealthDay)—An antibody can reduce retinal vascular leakage and inflammation in rat models of diabetic retinopathy, according to a study published online Oct. 1 in Diabetes.

Kyungwon Lee, from the University of Oklahoma Health Sciences Center in Oklahoma City, and colleagues investigated the effect of a monoclonal antibody targeting the E1E2 domain of Wnt coreceptor low-density lipoprotein receptor-related protein 6 (Mab2F1) on in vitro and in vivo.

The researchers found that Mab2F1 inhibited Wnt signaling in epithelial cells. Mab2F1 also reduced the levels of β-catenin as well as angiogenic and inflammatory factors induced by high-glucose medium in retinal endothelial cells. In rat models of ischemia-induced retinopathy and streptozotocin-induced diabetes, Mab2F1 significantly reduced retinal vascular leakage.

"In conclusion, Mab2F1 inhibits canonical Wnt signaling, vascular leakage, and inflammation in the retina of diabetic retinopathy models, suggesting its potential to be used as a therapeutic agent in combination with other antiangiogenic compounds," Lee and colleagues write.

Explore further: Apolipoproteins are biomarkers for diabetic retinopathy

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Apolipoproteins are biomarkers for diabetic retinopathy

June 29, 2012

(HealthDay) -- In patients with diabetes, with or without diabetic retinopathy, serum apolipoproteins (apos) are associated with markers of systemic and retinal microvascular dysfunction, according to a study published in ...

Low HDL cholesterol ups risk of diabetic nephropathy

August 22, 2012

(HealthDay) -- High-density lipoprotein cholesterol (HDL-C) is an independent risk factor for the development of diabetic nephropathy, but not retinopathy, in patients with type 2 diabetes, according to research published ...

Recommended for you

Do germs cause type 1 diabetes?

May 16, 2016

Germs could play a role in the development of type 1 diabetes by triggering the body's immune system to destroy the cells that produce insulin, new research suggests.

Melatonin signaling is a risk factor for type 2 diabetes

May 12, 2016

A sleeping pancreas releases less insulin, but how much insulin drops each night may differ from person to person, suggests a study published May 12, 2016 in Cell Metabolism. Up to 30 percent of the population may be predisposed ...

New gene for familial high cholesterol

May 12, 2016

New research from Denmark reveals the gene that explains one quarter of all familial hypercholesterolemia with very high blood cholesterol. Familial hypercholesterolemia is the most common genetic disorder leading to premature ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.