Monoclonal antibody effective therapy for diabetic retinopathy

Monoclonal antibody effective therapy for diabetic retinopathy
An antibody can reduce retinal vascular leakage and inflammation in rat models of diabetic retinopathy, according to a study published online Oct. 1 in Diabetes.

(HealthDay)—An antibody can reduce retinal vascular leakage and inflammation in rat models of diabetic retinopathy, according to a study published online Oct. 1 in Diabetes.

Kyungwon Lee, from the University of Oklahoma Health Sciences Center in Oklahoma City, and colleagues investigated the effect of a monoclonal antibody targeting the E1E2 domain of Wnt coreceptor low-density lipoprotein receptor-related protein 6 (Mab2F1) on in vitro and in vivo.

The researchers found that Mab2F1 inhibited Wnt signaling in epithelial cells. Mab2F1 also reduced the levels of β-catenin as well as angiogenic and inflammatory factors induced by high-glucose medium in retinal endothelial cells. In rat models of ischemia-induced retinopathy and streptozotocin-induced diabetes, Mab2F1 significantly reduced retinal vascular leakage.

"In conclusion, Mab2F1 inhibits canonical Wnt signaling, vascular leakage, and inflammation in the retina of diabetic retinopathy models, suggesting its potential to be used as a therapeutic agent in combination with other antiangiogenic compounds," Lee and colleagues write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Apolipoproteins are biomarkers for diabetic retinopathy

Jun 29, 2012

(HealthDay) -- In patients with diabetes, with or without diabetic retinopathy, serum apolipoproteins (apos) are associated with markers of systemic and retinal microvascular dysfunction, according to a study ...

Natural compound stops retinopathy

Jul 02, 2009

Researchers at the University of Oklahoma Health Sciences Center have found a way to use a natural compound to stop one of the leading causes of blindness in the United States. The research appears online ...

Recommended for you

Screening for diabetes at dental visits using oral blood

Feb 26, 2015

It is estimated that 8.1 million of the 29.1 million Americans living with diabetes are undiagnosed and many who have diabetes have poor glycemic control. Given that each year many Americans visit a dental provider but not ...

CBT, sertraline insufficient in diabetes and depression

Feb 26, 2015

(HealthDay)—For patients with diabetes and depression, improvements in depression are seen with cognitive behavioral therapy (CBT) or sertraline, with a significant advantage for sertraline, but glycemic ...

Early signs in young children predict type 1 diabetes

Feb 26, 2015

New research shows that it is possible to predict the development of type 1 diabetes. By measuring the presence of autoantibodies in the blood, it is possible to detect whether the immune system has begun to break down the ...

Daily menu plan reduces blood sugar significantly

Feb 25, 2015

A large group of people with diabetes who followed a menu plan created by University of Alberta nutrition researchers for just three months significantly reduced their blood sugar levels.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.