New biomaterials promote neuroregeneration after a brain injury

Professor Jose Miguel Soria, a member of the Institute of Biomedical Sciences, Universidad CEU Cardenal Herrera, has co-directed with Professor Manuel Monleón of the Universitat Politecnica de Valencia a study on the compatibility of polymeric biomaterials in the brain and its effectiveness to favour neuroregeneration in areas with some kind of damage or brain injury.  

The research carried out has shown that these types of implants, made of a biocompatible synthetic material, are colonized within two months by and irrigated by new blood vessels. This allows the generation, within these structures, of new neurons and glia, capable of repairing injured caused by trauma, stroke or neurodegenerative disease, among other causes.

The synthetic structures used in this study are made with a porous and biocompatible polymeric material called acrylate copolymer. In the first phase of the project, the structures have been studied in vitro by implanting them into neural tissue, and subsequently also in vivo, when implanted in two areas of the adult rat brain: the and the subventricular zone, the most important source of generation of adult .

The study has confirmed the high biocompatibility of polymeric materials, such as acrylate copolymer, with brain tissue and opens new possibilities of the effectiveness of the implementation of these structures in the brain, seeking optimum location for developing regenerative strategies of the central nervous system.

Furthermore, the results are particularly relevant when one considers that in the neuroregeneration capacity is more limited than in younger individuals and that the main impediment for this is the lack of revascularization of damaged tissue, something that the biomaterial studied has shown to favour.

The study, entitled "Channeled scaffolds implanted in adult rat brain", has been published in the Journal of Biomedical Materials Research.

More information: Martínez-Ramos, C. et al., Channeled scaffolds implanted in adult rat brain, J Biomed Mater Res Part A, 2012:100A:3276–3286. onlinelibrary.wiley.com/doi/10… jbm.a.34273/abstract

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Continuing the quest for better stroke therapies

19 hours ago

Helping people recover from the debilitating effects of a stroke is an immensely complex challenge that requires deep knowledge of neurophysiology as well as effective therapy. Advancing such knowledge to improve therapeutic ...

At last, hope for ALS patients?

22 hours ago

U of T researchers have found a missing link that helps to explain how ALS, one of the world's most feared diseases, paralyses and ultimately kills its victims. The breakthrough is helping them trace a path to a treatment ...

User comments